Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Antimicrob Agents Chemother. 2010 Jun;54(6):2699-703. doi: 10.1128/AAC.01624-09. Epub 2010 Apr 5.
The genetic structure of beta-lactamases in Acinetobacter genospecies 3 (AG3) isolates in Taiwan was studied to analyze their high rates of resistance to beta-lactams, including carbapenems (57.9%). bla(IMP-1) and bla(IMP-8) were located in a class 1 integron. bla(OXA-58) was bracketed by ISAba3. A novel TnpF-like integrase gene was identified upstream of bla(VEB-3). Adjacent to the 5' sequence of the bla(ADC) gene, folE was identified. Four new Acinetobacter-derived cephalosporinase (ADC) enzymes were found, which clustered phylogenetically with published AG3 ADC proteins.
本研究旨在分析台湾不动杆菌 3 群(AG3)分离株β-内酰胺酶的遗传结构,以解释其对包括碳青霉烯类(57.9%)在内的β-内酰胺类抗生素的高耐药率。bla(IMP-1)和 bla(IMP-8)位于一个Ⅰ类整合子上。bla(OXA-58)被 ISAba3 包围。在 bla(VEB-3)上游鉴定出一种新型的 TnpF 样整合酶基因。在 bla(ADC)基因的 5'序列附近鉴定出 folE。发现了 4 种新型的头孢菌素酶(ADC),与已发表的 AG3 ADC 蛋白在系统发育上聚类。