ISCR2，另一个 bla(VEB) 基因获得的载体。
ISCR2, another vehicle for bla(VEB) gene acquisition.
机构信息
Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud et Université Paris-Sud, Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2009 Nov;53(11):4940-3. doi: 10.1128/AAC.00414-09. Epub 2009 Aug 24.
Abstract
The expanded-spectrum beta-lactamase (ESBL) gene bla(VEB-1), identified worldwide in Enterobacteriaceae and Pseudomonas aeruginosa, is associated with either class 1 integrons or repeated elements. We report here the first association of bla(VEB-1a) with the insertion sequence ISCR2 in six Acinetobacter species isolates recovered from Argentina. That genetic structure was likely at the origin of the mobilization of this ESBL gene.
摘要
在肠杆菌科和铜绿假单胞菌中发现的广泛谱β-内酰胺酶（ESBL）基因 bla(VEB-1)与类 1 整合子或重复元件有关。我们在此报告 bla(VEB-1a)与插入序列 ISCR2 在从阿根廷分离的六种不动杆菌属物种中的首次关联。这种遗传结构可能是这种 ESBL 基因发生转移的起源。
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