Thiry L, Sprecher-Goldberger S, Bossens M, Neuray F
J Natl Cancer Inst. 1978 Mar;60(3):527-32. doi: 10.1093/jnci/60.3.527.
Tritiated thymidine incorporation into lymphocytes of 118 adult women was studied in the presence of mitomycin C-treated cells prepared from cell lines continuously producing Mason-Pfizer monkey virus (MPMV), baboon C-particle virus, or simian sarcoma virus (SSV) and in the presence of control cell lines documented for the absence of oncornaviruses. At the end of pregnancy, women who had 5-9 pregnancies showed a high frequency (53%) of specific positive responses to cells with MPMV antigens. The frequencies were 15% for pregnant women with smaller numbers of pregnancies and 3% for nonpregnant women with similar numbers of previous pregnancies as in the pregnancy group. None of these nonpregnant women had lymphocytes responding to stimulation by baboon C-virus antigens, but positive responses were obtained in 20 and 16% of the pregnant groups, respectively. No correlation was found between responses to MPMV or baboon C-virus antigens. Of 48 women (35 pregnant, 13 nonpregnant) who were tested for lymphocyte responses to SSV antigens, only 2 showed a positive response. The results indicated that two distinct antigens, related to MPMV and to baboon C-virus, may be expressed during pregnancy and may then induce a transient cell-mediated response.
在含有由持续产生梅森 - 辉瑞猴病毒（MPMV）、狒狒C型颗粒病毒或猿猴肉瘤病毒（SSV）的细胞系制备的经丝裂霉素C处理的细胞的情况下，以及在记录为不存在肿瘤病毒的对照细胞系存在的情况下，研究了118名成年女性淋巴细胞中氚标记胸腺嘧啶核苷的掺入情况。在妊娠末期，有5 - 9次妊娠的女性对带有MPMV抗原的细胞显示出高频率（53%）的特异性阳性反应。妊娠次数较少的孕妇的频率为15%，既往妊娠次数与妊娠组相似的非孕妇的频率为3%。这些非孕妇中没有一人的淋巴细胞对狒狒C病毒抗原的刺激有反应，但在妊娠组中分别有20%和16%获得了阳性反应。未发现对MPMV或狒狒C病毒抗原的反应之间存在相关性。在48名接受淋巴细胞对SSV抗原反应测试的女性（35名孕妇，13名非孕妇）中，只有2人显示出阳性反应。结果表明，与MPMV和狒狒C病毒相关的两种不同抗原可能在妊娠期间表达，然后可能诱导短暂的细胞介导反应。
