Wernicke D, Kurth R
Med Microbiol Immunol. 1981;170(2):135-43. doi: 10.1007/BF02122677.
Human sera were previously shown to possess antibodies capable of recognizing purified retrovirus envelope glycoproteins. In an extension of earlier studies we investigated sera from various groups of patients for an immune reaction against purified glycoprotein of the baboon endogenous virus BaEV. Reproducible demonstrations of oncovirus-like particles in human teratocarcinomas focused our main interest on sera from patients with testicular tumors. The specificity of the positive immune reaction of sera from these patients against BaEV gp 70 was analyzed in a competition RIAs with haptens and different cell lysates and experiments employing deglycosylated BaEV envelope antigen. From these experiments we conclude that the sera from teratocarcinoma patients contain naturally occurring, heterophil antibodies that react with the carbohydrate moieties of retrovirus envelope antigens.
先前已证明人血清中含有能够识别纯化逆转录病毒包膜糖蛋白的抗体。在早期研究的扩展中，我们研究了来自不同患者群体的血清，以检测其对狒狒内源性病毒BaEV纯化糖蛋白的免疫反应。人畸胎癌中可重复出现的肿瘤病毒样颗粒，使我们主要关注睾丸肿瘤患者的血清。通过与半抗原和不同细胞裂解物的竞争放射免疫分析以及使用去糖基化BaEV包膜抗原的实验，分析了这些患者血清对BaEV gp 70阳性免疫反应的特异性。从这些实验中我们得出结论，畸胎癌患者的血清中含有天然存在的嗜异性抗体，这些抗体与逆转录病毒包膜抗原的碳水化合物部分发生反应。
