Hirsch M S, Kelly A P, Chapin D S, Fuller T C, Black P H, Kurth R
Science. 1978 Mar 24;199(4335):1337-40. doi: 10.1126/science.204010.
Cell-mediated and humoral immune responses against antigens associated with primate C-type oncoviruses were evaluated in humans by microcytotoxicity and radioimmunoprecipitation assays. Five of six women tested sequentially during pregnancy developed selective cell-mediated reactivity against baboon endogenous virus (BEV)--infected human fibroblasts. Responsiveness peaked during the second and third trimesters and corresponded temporally with elevated antibody levels to BEV antigens. Similar cell-mediated reactivity was not observed in nonpregnant individuals. Selective cell-mediated reactivity directed against cells infected with the simian sarcoma virus-simian sarcoma associated virus complex (SSV--SSAV) was observed in four of 20 healthy adults (three of 14 nonpregnant, one of six pregnant). These observations suggest that cell-mediated reactivity against primate C-type oncoviruses is occasionally detected in healthy nonpregnant adults, but that during pregnancy both cell-mediated and humoral reactivity against BEV may become selectively expressed.
通过微细胞毒性和放射免疫沉淀试验，在人类中评估了针对与灵长类C型肿瘤病毒相关抗原的细胞介导免疫反应和体液免疫反应。在孕期进行连续检测的6名女性中，有5名对感染狒狒内源性病毒（BEV）的人类成纤维细胞产生了选择性细胞介导反应。反应性在孕中期和晚期达到峰值，并且在时间上与针对BEV抗原的抗体水平升高相对应。在未怀孕个体中未观察到类似的细胞介导反应。在20名健康成年人中，有4名（14名未怀孕者中的3名，6名怀孕者中的1名）对感染猿猴肉瘤病毒 - 猿猴肉瘤相关病毒复合物（SSV - SSAV）的细胞产生了选择性细胞介导反应。这些观察结果表明，在健康的未怀孕成年人中偶尔会检测到针对灵长类C型肿瘤病毒的细胞介导反应，但在怀孕期间，针对BEV的细胞介导反应和体液反应可能会选择性表达。
