Mandonnet Emmanuel, Delattre Jean-Yves, Tanguy Marie-Laure, Swanson Kristin R, Carpentier Antoine F, Duffau Hugues, Cornu Philippe, Van Effenterre Rémy, Alvord Ellsworth C, Capelle Laurent
Fédération de Neurologie Mazarin and INSERM U495, and Service de Neurochirurgie, Hôpital de la Salpêtrière (AP-HP), Paris.
Ann Neurol. 2003 Apr;53(4):524-8. doi: 10.1002/ana.10528.
Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8-4.4mm/year). Untreated low-grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow-up.
回顾性分析了27例未经治疗的世界卫生组织II级少突胶质细胞瘤或混合性胶质瘤患者的系列磁共振图像，以研究间变性转化前肿瘤生长的动力学。对平均肿瘤直径随时间的分析显示肿瘤持续生长。使用混合模型进行线性回归，发现平均斜率为每年4.1毫米（95%置信区间，3.8-4.4毫米/年）。未经治疗的低级别少突胶质细胞瘤或混合性胶质瘤在其癌前阶段持续生长，并且其生长模式可以在相对较窄的范围内预测。这些发现可能有助于优化患者的管理和随访。
