评估慢性阻塞性肺疾病患者使用 I-neb AAD 系统的患者报告结局和生活质量。
Evaluation of patient-reported outcomes and quality of life with the I-neb AAD system in patients with chronic obstructive pulmonary disease.
机构信息
Glenfield Hospital, Leicester, United Kingdom.
出版信息
J Aerosol Med Pulm Drug Deliv. 2010 Apr;23 Suppl 1(Suppl 1):S61-70. doi: 10.1089/jamp.2009.0767.
BACKGROUND
The I-neb Adaptive Aerosol Delivery (AAD) System is a novel portable mesh nebulizer that provides patient feedback regarding adherence to prescribed treatment and compliance with the correct use of the device.
METHODS
This multicenter study was composed of 98 patients aged 53-80 years with Chronic Obstructive Pulmonary Disease (COPD). The primary variables were ease of use and satisfaction, which were assessed after 3 months of use of the I-neb AAD System (assessed at visit 2) and after 3 months of use of the patient's previous nebulizer system (assessed at visit 1) using matched questions from pre- and poststudy questionnaires. Quality of life was also assessed at visits 1 and 2 using the validated Chronic Respiratory Questionnaire (CRQ), which consists of dyspnea, emotional function, fatigue, and mastery domains. Differences in the distribution of responses between the pre- and poststudy ease of use and satisfaction questions were analyzed using the Marginal Homogeneity test. Differences in mean CRQ scores between the pre- and poststudy assessments were analyzed using the Wilcoxon Signed-Rank test.
RESULTS
Patient responses on the ease of use and satisfaction questions significantly (p < or = 0.001) favored the I-neb AAD System compared with the patient's previous nebulizer system. In addition, significant (p < or = 0.015) improvements in the CRQ dimensions of dyspnea and fatigue were reported with the I-neb AAD System compared with the patients' previous nebulizer systems.
CONCLUSIONS
The results from this study demonstrated that patients were more satisfied with the I-neb AAD System and found it easier to use than their previous nebulizer systems. In addition, the I-neb AAD System significantly improved dyspnea and fatigue compared with the patients' previous nebulizer systems, which may reflect improved adherence or more correct use of the nebulizer system with the I-neb AAD System.
背景
I-neb 自适应雾化输送（AAD）系统是一种新型的便携式网孔雾化器，可提供有关患者对规定治疗的依从性和对设备正确使用的反馈。
方法
这项多中心研究由 98 名年龄在 53-80 岁的慢性阻塞性肺疾病（COPD）患者组成。主要变量是易用性和满意度，这是在使用 I-neb AAD 系统 3 个月后（在第 2 次就诊时评估）和使用患者之前的雾化器系统 3 个月后（在第 1 次就诊时评估）使用来自研究前后问卷的匹配问题评估的。使用经过验证的慢性呼吸系统问卷（CRQ），在第 1 和第 2 次就诊时还评估了生活质量，该问卷由呼吸困难、情绪功能、疲劳和掌握领域组成。使用边缘同质性检验分析了预研究和后研究易用性和满意度问题的分布之间差异。使用 Wilcoxon 符号秩检验分析了预研究和后研究评估之间 CRQ 评分的均值差异。
结果
与患者之前的雾化器系统相比，患者对易用性和满意度问题的回答明显（p < or = 0.001）倾向于 I-neb AAD 系统。此外，与患者之前的雾化器系统相比，使用 I-neb AAD 系统时，呼吸困难和疲劳的 CRQ 维度显著（p < or = 0.015）改善。
结论
这项研究的结果表明，患者对 I-neb AAD 系统更满意，并且发现它比他们之前的雾化器系统更容易使用。此外，与患者之前的雾化器系统相比，I-neb AAD 系统显著改善了呼吸困难和疲劳，这可能反映了使用 I-neb AAD 系统时的依从性提高或对雾化器系统的使用更正确。
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