Chan John Gar Yan, Wong Jennifer, Zhou Qi Tony, Leung Sharon Shui Yee, Chan Hak-Kim
Respiratory Technology, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, The University of Sydney, Sydney, 2037, NSW, Australia.
AAPS PharmSciTech. 2014 Aug;15(4):882-97. doi: 10.1208/s12249-014-0114-y. Epub 2014 Apr 12.
Inhaled pharmaceuticals are formulated and delivered differently according to the therapeutic indication. However, specific device-formulation coupling is often fickle, and new medications or indications also demand new strategies. The discontinuation of chlorofluorocarbon propellants has seen replacement of older metered dose inhalers with dry powder inhaler formulations. High-dose dry powder inhalers are increasingly seen as an alternative dosage form for nebulised medications. In other cases, new medications have completely bypassed conventional inhalers and been formulated for use with unique inhalers such as the Staccato® device. Among these different devices, integration of software and electronic assistance has become a shared trend. This review covers recent device and formulation advances that are forming the current landscape of inhaled therapeutics.
吸入式药物根据治疗适应症的不同而采用不同的配方和给药方式。然而，特定的装置与配方的搭配往往不稳定，新药物或新适应症也需要新的策略。随着氯氟烃推进剂的停用，旧的定量吸入器已被干粉吸入器配方所取代。高剂量干粉吸入器越来越被视为雾化药物的替代剂型。在其他情况下，新药物完全绕过了传统吸入器，采用了如Staccato®装置等独特吸入器的配方。在这些不同的装置中，软件与电子辅助的整合已成为一个共同趋势。本综述涵盖了构成当前吸入治疗格局的近期装置和配方进展。
