Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ont., Canada.
J Innate Immun. 2009;1(1):4-17. doi: 10.1159/000141865. Epub 2008 Jun 25.
Integrins are a large family of heterodimeric transmembrane cell adhesion receptors. During the last decade, it has become clear that integrins significantly participate in various host-pathogen interactions involving pathogenic bacteria, fungi, and viruses. Many bacteria possess adhesins that can bind either directly or indirectly to integrins. However, there appears to be an emerging role for integrins beyond simply adhesion molecules. Given the conserved nature of integrin structure and function, and the diversity of the pathogens which use integrins, it appears that they may act as pattern recognition receptors important for the innate immune response. Several clinically significant bacterial pathogens target lung epithelial integrins, and this review will focus on exploring various structures and mechanisms involved in these interactions.
整合素是一大类异二聚体跨膜细胞黏附受体。在过去的十年中，已经很清楚整合素在涉及病原菌（细菌、真菌和病毒）的各种宿主-病原体相互作用中显著参与。许多细菌具有黏附素，可直接或间接与整合素结合。然而，整合素的作用似乎不仅仅是作为黏附分子。鉴于整合素结构和功能的保守性，以及利用整合素的病原体的多样性，它们可能作为先天免疫反应的模式识别受体发挥作用。几种临床上重要的细菌病原体以肺上皮整合素为靶标，本综述将重点探讨这些相互作用中涉及的各种结构和机制。
