Medical Clinic III, University of Schleswig-Holstein, Campus Lübeck, 23538 Lübeck, Germany.
Cell Tissue Res. 2011 Jan;343(1):167-74. doi: 10.1007/s00441-010-1048-7. Epub 2010 Oct 9.
As the human lung is exposed to a variety of microbial pathogens in the environment, a first line of defense is built up by pulmonary cells like bronchial/alveolar epithelial cells and alveolar macrophages. These cells express several pattern recognition receptors (PRRs) recognizing highly conserved microbial motifs and initiating the production of chemokines and pro- and anti-inflammatory cytokines acting as transmembrane or intracellular receptors. This might not only lead to acute but also to chronic inflammation which is discussed as an underlying mechanism in the pathogenesis of different lung diseases.
由于人类肺部会接触到环境中的各种微生物病原体，肺部细胞（如支气管/肺泡上皮细胞和肺泡巨噬细胞）会形成第一道防线。这些细胞表达多种模式识别受体（PRRs），识别高度保守的微生物基序，并启动趋化因子和促炎及抗炎细胞因子的产生，这些细胞因子作为跨膜或细胞内受体发挥作用。这不仅可能导致急性炎症，还可能导致慢性炎症，这被认为是不同肺部疾病发病机制中的一个潜在机制。
