Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
Yonsei Med J. 2010 May;51(3):454-6. doi: 10.3349/ymj.2010.51.3.454.
Fluoroquinolones (FQs) represent a major class of antimicrobials that have a high potential as therapeutic agents. Although FQs are generally safe for the use as antimicrobials, they may induce tendinopathic complications such as tendinitis and tendon rupture. A number of factors have been suggested to further predispose a patient to such injuries. Hitherto, a few published cases on tendon disorders have implicated levofloxacin, a more recently introduced FQ. Here, we report a patient with levofloxacin-induced Achilles tendinitis, who exhibited no known predisposing factors. A 20-year-old man without any history of disease or medication presented with community-acquired pneumonia. Levofloxacin was administered and 3 days later, he complained of pain in the left Achilles tendon and revealed redness and swelling in the area. On suspecting Achilles tendinitis, levofloxacin treatment was discontinued, and the tendinitis subsequently improved. To our knowledge, this is the first case report on FQ-induced Achilles tendinitis in Korea.
氟喹诺酮类（FQs）是一类具有很大治疗潜力的重要抗生素。尽管 FQs 通常作为抗生素使用是安全的，但它们可能会引起肌腱病并发症，如肌腱炎和肌腱断裂。有许多因素被认为会进一步使患者容易受到此类损伤。迄今为止，一些已发表的肌腱疾病病例涉及左氧氟沙星，这是一种最近推出的 FQ。在这里，我们报告了一例左氧氟沙星引起的跟腱炎患者，他没有任何已知的易患因素。一名 20 岁的男性，无任何疾病或用药史，患有社区获得性肺炎。给予左氧氟沙星治疗，3 天后，他诉左跟腱疼痛，并在该区域出现红肿和肿胀。怀疑为跟腱炎后，停止使用左氧氟沙星治疗，随后跟腱炎得到改善。据我们所知，这是韩国首例 FQ 引起的跟腱炎病例报告。
