宿主对白念珠菌的反应：Th17 细胞与黏膜念珠菌病。
Host responses to Candida albicans: Th17 cells and mucosal candidiasis.
机构信息
University at Buffalo, SUNY, Department of Oral Biology, Buffalo, NY, USA.
出版信息
Microbes Infect. 2010 Jul;12(7):518-27. doi: 10.1016/j.micinf.2010.03.013. Epub 2010 Apr 8.
Abstract
Candida albicans causes mucosal and disseminated candidiasis, which represent serious problems for the rapidly expanding immunocompromised population. Until recently, Th1-mediated immunity was thought to confer the primary protection, particularly for oral candidiasis. However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis.
摘要
白色念珠菌可引起黏膜和播散性念珠菌病，这对迅速扩大的免疫功能低下人群构成严重威胁。直到最近，人们还认为 Th1 介导的免疫可提供主要保护，特别是针对口腔念珠菌病。然而，新出现的数据表明，新定义的 Th17 细胞群似乎在黏膜念珠菌病中发挥主要作用。
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