Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Cancer Causes Control. 2010 Aug;21(8):1305-14. doi: 10.1007/s10552-010-9558-x. Epub 2010 Apr 10.
To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes.
In a pooled analysis of primary data of seven prospective cohorts including 458,070 men and 485,689 women, we identified 2,454 patients with incident pancreatic cancer during an average 6.9 years of follow-up. Cox proportional hazard regression models were used in data analysis.
In a random-effects meta-analysis, for every 5 kg/m(2) increment in BMI, the summary relative risk (RR) was 1.06 (95% confidence interval (CI) 0.99-1.13) for men and 1.12 (95% CI 1.05-1.19) for women. The aggregate analysis showed that compared with normal weight (BMI: 18.5 to <25), the adjusted RR was 1.13 (95% CI 1.03-1.23) for overweight (BMI: 25 to <30) and 1.19 (95% CI 1.05-1.35) for obesity class I (BMI: 30 to <35). Tests of interactions of BMI effects by other risk factors were not statistically significant. Every 5 kg/m(2) increment in BMI was associated with an increased risk of pancreatic cancer among never and former smokers, but not among current smokers (P-interaction = 0.08).
The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.
研究体重指数（BMI，kg/m²）与胰腺癌风险之间的正相关关系是否受年龄、性别、吸烟状况、身体活动和糖尿病史的影响。
在对包括 458070 名男性和 485689 名女性在内的 7 项前瞻性队列的原始数据进行的汇总分析中，我们发现 458070 名男性和 485689 名女性在平均 6.9 年的随访中发生了 2454 例胰腺癌新发病例。数据分析采用 Cox 比例风险回归模型。
在随机效应荟萃分析中，对于 BMI 每增加 5kg/m²，男性的汇总相对风险（RR）为 1.06（95%置信区间（CI）为 0.99-1.13），女性为 1.12（95%CI 为 1.05-1.19）。汇总分析表明，与正常体重（BMI：18.5 至<25）相比，超重（BMI：25 至<30）的调整 RR 为 1.13（95%CI 为 1.03-1.23），肥胖 I 级（BMI：30 至<35）为 1.19（95%CI 为 1.05-1.35）。BMI 效应与其他危险因素之间的交互作用检验无统计学意义。BMI 每增加 5kg/m²，与从不吸烟者和前吸烟者的胰腺癌风险增加相关，但与现吸烟者无关（P 交互=0.08）。
现有证据表明，高 BMI 是胰腺癌的独立危险因素。
