Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America ; Tacoma-Pierce County Health Department, Tacoma, Washington, United States of America.
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America.
PLoS One. 2014 Jan 15;9(1):e85149. doi: 10.1371/journal.pone.0085149. eCollection 2014.
Few studies have examined the association between body mass index (BMI: kg/m(2)) and pancreatic cancer risk in Asian populations. We examined this relationship in 51,251 Chinese men and women aged 45-74 who enrolled between 1993 and 1998 in the population based, prospective Singapore Chinese Health Study. Data were collected through in-person interviews. By December 31, 2011, 194 cohort participants had developed pancreatic cancer. A Cox proportional hazards model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). We hypothesized the association between BMI and pancreatic cancer risk may vary by smoking status (ever v. never) and there was evidence for this as the interaction between BMI and smoking status was significant (p = 0.018). Among ever smokers, being classified as underweight (BMI <18.5 kg/m(2)), was associated with a significantly elevated risk of pancreatic cancer relative to smokers with a BMI of 21.5-24.4 kg/m(2) (HR = 1.99, 95% CI = 1.03-3.84). This association was strengthened after exclusion of the first three years of follow-up time. Among never smokers, there was no association between BMI and pancreatic cancer risk. However, after excluding pancreatic cancer cases and person-years in the first three years of follow-up, never smokers with a BMI ≥ 27.5 kg/m(2) showed a suggestive increased risk of pancreatic cancer relative to never smokers with a BMI of 21.5-24.4 kg/m(2) (HR = 1.75, 95% CI = 0.93-3.3). In conclusion, Singaporean Chinese who were underweight with a history of smoking had an increased risk of developing pancreatic cancer, whereas there was no significant association between BMI and pancreatic cancer in never smokers.
很少有研究探讨身体质量指数（BMI：kg/m(2)）与亚洲人群胰腺癌风险之间的关系。我们在 1993 年至 1998 年期间参加了基于人群的前瞻性新加坡华人健康研究的 51251 名 45-74 岁的中国男性和女性中研究了这种关系。数据通过面对面访谈收集。截至 2011 年 12 月 31 日，194 名队列参与者已患上胰腺癌。使用 Cox 比例风险模型估计风险比（HR）及其 95%置信区间（95%CI）。我们假设 BMI 与胰腺癌风险之间的关联可能因吸烟状况（曾经吸烟与从不吸烟）而异，并且这种关联存在证据，因为 BMI 和吸烟状况之间的相互作用具有统计学意义（p = 0.018）。在曾经吸烟者中，与 BMI 为 21.5-24.4kg/m(2)的吸烟者相比，体重不足（BMI <18.5kg/m(2)）与胰腺癌风险显著升高相关（HR = 1.99，95%CI 1.03-3.84）。在排除前三年随访时间后，这种关联得到了加强。在从不吸烟者中，BMI 与胰腺癌风险之间没有关联。然而，在排除前三年的随访时间内的胰腺癌病例和人年数后，BMI≥27.5kg/m(2)的从不吸烟者与 BMI 为 21.5-24.4kg/m(2)的从不吸烟者相比，胰腺癌的风险呈增加趋势（HR = 1.75，95%CI 0.93-3.3）。总之，有吸烟史的新加坡华人体重不足者患胰腺癌的风险增加，而从不吸烟者的 BMI 与胰腺癌之间无显著关联。
