Egger P, Duggleby S, Hobbs R, Fall C, Cooper C
MRC Environmental Epidemiology Unit, Southampton General Hospital.
J Epidemiol Community Health. 1996 Feb;50(1):47-50. doi: 10.1136/jech.50.1.47.
To test the hypothesis that cigarette smoking is associated with reduced bone mineral density in elderly men and women.
Cross sectional study.
These comprised 224 men and 186 women aged 61-73 years, born and resident in East Hertfordshire.
Lumbar spine and femoral neck bone mineral density (BMD) were determined by dual energy x ray absorptiometry.
After adjusting for potential confounding variables, men who were current smokers were found to have a lumbar spine BMD that was 7.3% (95% CI 0.4, 14.2) lower than men who had never smoked. Similarly, women who were current smokers had a BMD value that was 7.7% (95% CI 0.3, 15.6) lower than in women who had never smoked. The difference at the femoral neck was smaller and not statistically significant. For both men and women, each decade of smoking was associated with a reduction of 0.015 g/cm2 in BMD at the lumbar spine (95% CI: men 0.002, 0.027; women 0.003, 0.028). At the femoral neck the reduction in BMD was 0.011 g/cm2 (95% CI 0.003, 0.020) for men and 0.004 g/cm2 (95% CI -0.003, 0.012) for women with each decade of smoking.
The results show an adverse effect of smoking on BMD which was most noticeable at the lumbar spine, and seemed stronger in men than women. This effect could not be explained by differences in life style between smokers and nonsmokers.
验证吸烟与老年男性和女性骨密度降低相关的假说。
横断面研究。
这些研究对象包括224名男性和186名女性，年龄在61至73岁之间，出生并居住在东赫特福德郡。
采用双能X线吸收法测定腰椎和股骨颈的骨密度（BMD）。
在对潜在的混杂变量进行校正后，发现当前吸烟者的腰椎骨密度比从不吸烟者低7.3%（95%可信区间0.4, 14.2）。同样，当前吸烟女性的骨密度值比从不吸烟女性低7.7%（95%可信区间0.3, 15.6）。股骨颈处的差异较小且无统计学意义。对于男性和女性，每吸烟十年，腰椎骨密度降低0.015 g/cm²（95%可信区间：男性0.002, 0.027；女性0.003, 0.028）。在股骨颈处，男性每吸烟十年骨密度降低0.011 g/cm²（95%可信区间0.003, 0.020），女性每吸烟十年骨密度降低0.004 g/cm²（95%可信区间 -0.003, 0.012）。
结果显示吸烟对骨密度有不良影响，在腰椎处最为明显，且男性似乎比女性更明显。这种影响无法用吸烟者和非吸烟者生活方式的差异来解释。
