Oei T P
Pharmacol Biochem Behav. 1978 Jan;8(1):25-9. doi: 10.1016/0091-3057(78)90118-1.
The present study evaluated the differential contributions of the central and peripheral catecholaminergic systems in aversive learning using trace-conditioning procedure. Twenty-seven male Wistar rats were randomly assigned to one of the three groups: central drug and peripheral saline (CDPS) injections, central saline and peripheral drug (CSPD) injections, and central saline and peripheral saline (CSPS) injections. Results showed that: (1) the rate of acquisition and the overall avoidance responses for the drug treated groups was significantly poorer than the control group; (2) there was no significant difference in performance between the two drug treated groups; and, (3) neither central nor peripheral catecholamine depletion had a significant effect on the secretion of plasma corticosterone. The findings failed to confirm the hypotheses (1) that central CA depletion is more detrimental than peripheral NA depletion, (2) that plasma 11-OHCS plays a mediating role in the acquisition of avoidance and escape responses in rats depleted of catecholaminergic systems.
本研究采用痕迹条件反射程序评估了中枢和外周儿茶酚胺能系统在厌恶性学习中的不同作用。27只雄性Wistar大鼠被随机分为三组之一：中枢注射药物和外周注射生理盐水（CDPS）、中枢注射生理盐水和外周注射药物（CSPD）、中枢注射生理盐水和外周注射生理盐水（CSPS）。结果显示：（1）药物处理组的习得率和总体回避反应显著低于对照组；（2）两个药物处理组之间的表现无显著差异；（3）中枢或外周儿茶酚胺耗竭对血浆皮质酮的分泌均无显著影响。这些发现未能证实以下假设：（1）中枢儿茶酚胺耗竭比外周去甲肾上腺素耗竭更具危害性；（2）血浆11-羟基皮质类固醇在儿茶酚胺能系统耗竭的大鼠的回避和逃避反应习得中起中介作用。
