Oei T P, King M G
Pharmacol Biochem Behav. 1978 Aug;9(2):243-7. doi: 10.1016/0091-3057(78)90171-5.
Thirty-two Wistar rats were used to investigate the effects of extended training on avoidance performance of rats depleted of Catecholamines. They were injected with 6-hydroxydopamine either (i) intracisternally, (ii) intraperitoneally, or (iii) both IP and IC, and trained on the two-way shuttlebox avoidance task. The results on peripheral noradrenaline depletion led to the conclusion that extended training ameliorates the observed behavioural deficit significantly back to the level of controls. The conclusion that is indicated by the present central catecholamine depletion are: (i) central catecholamine depletion has long term effect on behavioural deficit, (ii) central depletion is more detrimental to avoidance learning than peripheral depletion, and (iii) plasma corticosterone plays no significant mediating roles.
32只Wistar大鼠被用于研究长期训练对去甲肾上腺素耗竭大鼠回避行为的影响。它们被注射6-羟基多巴胺，注射方式如下：(i) 脑池内注射，(ii) 腹腔内注射，或(iii) 腹腔内和脑池内联合注射，然后在双向穿梭箱回避任务中接受训练。外周去甲肾上腺素耗竭的实验结果得出结论：长期训练能显著改善观察到的行为缺陷，使其恢复到对照水平。目前中枢去甲肾上腺素耗竭实验得出的结论如下：(i) 中枢去甲肾上腺素耗竭对行为缺陷有长期影响；(ii) 中枢去甲肾上腺素耗竭比外周去甲肾上腺素耗竭对回避学习的损害更大；(iii) 血浆皮质酮没有显著的中介作用。
