Oei T P, Ng C P
Pharmacol Biochem Behav. 1978 May;8(5):553-6. doi: 10.1016/0091-3057(78)90387-8.
Rats were injected with 6-hydroxydopamine either intracisternally, intraperitoneally, or both, in order to examine the effects of central vs. peripheral catecholamine depletion on a step-down passive avoidance task. All rats acquired the response at the end of the five asquisition trials but the rates of acquisition of the drug-treated groups were siginificantly different from the control group. No significant difference in the performance results were observed between groups during the extinction period. These findings failed to confirm the hypothesis that an intact central and/or peripheral catecholaminergic systems may be necessary for the acquisition and extinction of a step-down passive avoidance response. In addition, this study also showed that plasma corticosterone levels in the rats depleted of central or peripheral catecholamine did not differ significantly from each other after passive avoidance training.
为了研究中枢与外周儿茶酚胺耗竭对一步被动回避任务的影响，分别向大鼠脑池内、腹腔内注射6-羟基多巴胺，或两者同时注射。所有大鼠在五次习得试验结束时都获得了该反应，但药物治疗组的习得率与对照组有显著差异。在消退期，各实验组之间的行为表现结果未观察到显著差异。这些结果未能证实这样的假设，即完整的中枢和/或外周儿茶酚胺能系统对于一步被动回避反应的习得和消退可能是必需的。此外，本研究还表明，在被动回避训练后，中枢或外周儿茶酚胺耗竭的大鼠血浆皮质酮水平彼此之间没有显著差异。
