Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Clin Infect Dis. 2010 May 15;50 Suppl 3(Suppl 3):S102-7. doi: 10.1086/651480.
As described elsewhere in this supplement, development of effective methods for prevention of human immunodeficiency virus (HIV) infection has proven to be more challenging than development of effective treatment for the disease. New strategies to control the HIV epidemic are urgently needed; this urgency creates interest in investigation of the possibility of using antiretroviral treatment in combination with other modalities to control the epidemic. This article summarizes current knowledge concerning prevention modalities in the context of the drivers of the HIV epidemic in specific communities, describes challenges in investigating test-and-treat strategies, and proposes research directions for addressing these challenges to investigate the impact of prevention strategies on mitigation of epidemics.
如本增刊其他部分所述，开发有效的人类免疫缺陷病毒 (HIV) 感染预防方法比开发有效的疾病治疗方法更具挑战性。迫切需要新的策略来控制 HIV 流行；这种紧迫性使人们有兴趣研究是否可以结合其他方法使用抗逆转录病毒治疗来控制疫情。本文总结了在特定社区的 HIV 流行驱动因素背景下有关预防方式的现有知识，描述了研究检测和治疗策略所面临的挑战，并提出了研究方向，以探讨预防策略对减轻疫情的影响。
