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通量平衡分析考虑代谢物稀释。

Flux balance analysis accounting for metabolite dilution.

机构信息

The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.

出版信息

Genome Biol. 2010;11(4):R43. doi: 10.1186/gb-2010-11-4-r43. Epub 2010 Apr 16.

DOI:10.1186/gb-2010-11-4-r43
PMID:20398381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2884546/
Abstract

Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions.

摘要

通量平衡分析是一种预测代谢网络中稳态通量分布的常用方法，它考虑了合成一组预定的必需生物量前体的生长需求。在某些情况下，忽略了平衡中间代谢物稀释所需的合成的生长需求会导致通量平衡分析产生错误预测。在这里，我们提出了代谢物稀释通量平衡分析，解决了这个问题，从而提高了代谢表型预测的准确性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/ddd7f9629360/gb-2010-11-4-r43-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/c37fab78d92e/gb-2010-11-4-r43-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/e2feac82ae09/gb-2010-11-4-r43-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/0fcba718817f/gb-2010-11-4-r43-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/ddd7f9629360/gb-2010-11-4-r43-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/c37fab78d92e/gb-2010-11-4-r43-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/e2feac82ae09/gb-2010-11-4-r43-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/0fcba718817f/gb-2010-11-4-r43-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b6/2884546/ddd7f9629360/gb-2010-11-4-r43-4.jpg

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