Department of Clinical Laboratory, College of Pharmacy, University of Karbala, Karbala, Iraq.
Mycoses. 2011 Jul;54(4):345-9. doi: 10.1111/j.1439-0507.2010.01876.x. Epub 2010 Apr 6.
For determining the toxic effect of heavy metals on dermatophytes, eight heavy metals were tested using colony diameter method. Cadmium showed high toxicity effects on isolated fungi at minimal inhibitory concentration of 27 μg ml(-1) for Trichophyton mentagrophytes and of 20 μg ml(-1) for Epidermophyton floccosum, while iron enhanced dermatophytic growth. Other heavy metals revealed variable effect on isolated fungi. Susceptibility of E. floccosum to the activity of tested metals was greater than those of T. mentagrophytes. In conclusion, cadmium and silver are regarded to be the effective metals to prevent the development of two isolated species of dermatophytes. Growth of fungi in the presence of iron was greater than control.
为了确定重金属对皮肤真菌的毒性作用，采用菌落直径法对 8 种重金属进行了测试。结果表明，镉对分离真菌的最小抑菌浓度为 27μg/ml（对须癣毛癣菌）和 20μg/ml（对絮状表皮癣菌），具有较高的毒性作用，而铁则增强了皮肤真菌的生长。其他重金属对分离真菌的作用不同。絮状表皮癣菌对试验金属的敏感性大于须癣毛癣菌。总之，镉和银被认为是有效抑制两种分离皮肤真菌生长的金属。在铁存在的情况下，真菌的生长大于对照。
