非洲 2 型糖尿病患者高尿酸血症的患病率：系统评价和荟萃分析。
Prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa: a systematic review and meta-analysis.
机构信息
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, PO.Box 1145, Dessie, Ethiopia.
Department of Medical Laboratory Sciences, College of Health Sciences, Mizan-Tepi University, PO.Box 260, Mizan, Ethiopia.
出版信息
BMC Endocr Disord. 2023 Jul 18;23(1):153. doi: 10.1186/s12902-023-01408-0.
BACKGROUND
Hyperuricemia increases morbidity and mortality in type 2 diabetic individuals. It is linked to the expansion of diabetes and cardiovascular diseases indicators, as well as being a significant predictor of coronary artery disease. It also leads to a poor prognosis and increment of diabetic complications including diabetic neuropathy, retinopathy, and nephropathy. Therefore, this systematic review and meta-analysis was aimed to determine the pooled prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa.
METHODS
We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. To identify relevant articles, we searched electronic databases such as PubMed, Google Scholar, African Journal Online, Science Direct, Embase, ResearchGate, Scopus, and Web of Sciences. The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. Statistical analysis was performed using Stata 14.0 software. To evaluate heterogeneity, we utilized Cochran's Q test and I statistics. Publication bias was assessed through the examination of a funnel plot and Egger's test. The pooled prevalence was estimated using a random effect model. Furthermore, sub-group and sensitivity analyses were conducted.
RESULTS
The overall pooled prevalence of hyperuricemia among type 2 diabetic patients in Africa was 27.28% (95% CI: 23.07, 31.49). The prevalence was highest in Central Africa 33.72% (95% CI: 23.49, 43.95), and lowest in North Africa 24.72% (95% CI: 14.38, 35.07). Regarding sex, the pooled prevalence of hyperuricemia among female and male type 2 diabetic patients was 28.02% (95% CI: 22.92, 33.48) and 28.20% (95% CI: 22.92, 33.48), respectively.
CONCLUSION
This systematic review and meta-analysis showed a high prevalence of hyperuricemia among type 2 diabetic patients. So, regular screening and diagnosis of hyperuricemia required for preventing its pathological effects and contribution to chronic complications of diabetes.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO (2022: CRD42022331279).
背景
高尿酸血症会增加 2 型糖尿病患者的发病率和死亡率。它与糖尿病和心血管疾病指标的扩大有关，也是冠心病的重要预测指标。它还导致预后不良，并增加糖尿病并发症，包括糖尿病神经病变、视网膜病变和肾病。因此，本系统评价和荟萃分析旨在确定非洲 2 型糖尿病患者高尿酸血症的汇总患病率。
方法
我们按照系统评价和荟萃分析的首选报告项目指南进行了系统评价和荟萃分析。为了确定相关文章，我们检索了电子数据库，如 PubMed、Google Scholar、African Journal Online、Science Direct、Embase、ResearchGate、Scopus 和 Web of Sciences。使用纽卡斯尔-渥太华质量评估量表评估纳入研究的质量。使用 Stata 14.0 软件进行统计分析。为了评估异质性，我们使用 Cochran's Q 检验和 I 统计量。通过检查漏斗图和 Egger 检验来评估发表偏倚。使用随机效应模型估计汇总患病率。此外，还进行了亚组和敏感性分析。
结果
非洲 2 型糖尿病患者高尿酸血症的总体汇总患病率为 27.28%（95%CI：23.07，31.49）。中非的患病率最高，为 33.72%（95%CI：23.49，43.95），北非的患病率最低，为 24.72%（95%CI：14.38，35.07）。关于性别，女性和男性 2 型糖尿病患者高尿酸血症的汇总患病率分别为 28.02%（95%CI：22.92，33.48）和 28.20%（95%CI：22.92，33.48）。
结论
本系统评价和荟萃分析显示，2 型糖尿病患者高尿酸血症的患病率较高。因此，需要定期筛查和诊断高尿酸血症，以预防其病理作用并减少糖尿病慢性并发症的发生。
系统评价注册
PROSPERO（2022：CRD42022331279）。
Zotero 插件