约旦2型糖尿病患者高尿酸血症的患病率及相关因素
Prevalence of Hyperuricemia and Associated Factors Among Type 2 Diabetic Patients in Jordan.
作者信息
Abujbara Mousa, Al Hourani Huda M, Al-Raoush Reem Ibrahim, Khader Yousef S, Ajlouni Kamel
机构信息
The National Centre (Institute) for Diabetes, Endocrinology and Genetics, The University of Jordan, Amman, Jordan.
Department of Clinical Nutrition and Dietetics, Faculty of Applied Health Sciences, The Hashemite University, Zarqa, Jordan.
出版信息
Int J Gen Med. 2022 Aug 16;15:6611-6619. doi: 10.2147/IJGM.S376857. eCollection 2022.
BACKGROUND
Previous studies showed variable estimate of the prevalence of hyperuricemia in patients with type 2 diabetes mellitus (T2DM). The prevalence of hyperuricemia and associated risk factors in Jordanian patients with T2DM is largely unknown. Therefore, this study aimed to determine the prevalence of hyperuricemia and its associated factors in Jordanian patients with T2DM.
METHODS
A cross-sectional study was conducted on 655 patients with T2DM. A structured questionnaire was used to collect socio-demographic data. In addition, records of the study subjects were reviewed to obtain other clinical data. Weight, height, and waist circumference were measured, and body mass index was calculated. Lipid profile, serum uric acid and glycated haemoglobin were analysed. The study was conducted in accordance with the Declaration of Helsinki. An informed written consent was obtained from each participant. The confidentiality of the information was assured and only used for scientific purposes.
RESULTS
Overall, the prevalence of hyperuricemia was 28.1%. Female gender (OR: 2.37; 95%, CI: 1.63-3.45), intake of angiotensin-converting enzyme (ACE) and angiotensin-II receptor blockers (ARBs) (OR: 1.68; 95%, CI: 1.12-2.50), intake of β-blockers (OR: 2.20; 95%, CI: 1.51-3.22), increased waist circumference (OR: 3.17; 95%, CI: 1.39-7.22) and family history of hyperuricemia (OR: 2.56; 95%, CI: 1.57-4.16) were associated with increased odds of hyperuricemia.
CONCLUSION
Hyperuricemia was high among type 2 diabetic patients, and screening test will be useful for those patients.
背景
先前的研究显示，2型糖尿病（T2DM）患者高尿酸血症患病率的估计值存在差异。约旦T2DM患者高尿酸血症的患病率及其相关危险因素在很大程度上尚不清楚。因此，本研究旨在确定约旦T2DM患者高尿酸血症的患病率及其相关因素。
方法
对655例T2DM患者进行了一项横断面研究。使用结构化问卷收集社会人口统计学数据。此外，查阅研究对象的记录以获取其他临床数据。测量体重、身高和腰围，并计算体重指数。分析血脂、血清尿酸和糖化血红蛋白。本研究按照《赫尔辛基宣言》进行。获得了每位参与者的知情书面同意。确保信息保密且仅用于科学目的。
结果
总体而言，高尿酸血症的患病率为28.1%。女性（比值比：2.37；95%置信区间：1.63 - 3.45）、服用血管紧张素转换酶（ACE）抑制剂和血管紧张素II受体阻滞剂（ARB）（比值比：1.68；95%置信区间：1.12 - 2.50）、服用β受体阻滞剂（比值比：2.20；95%置信区间：1.51 - 3.22）、腰围增加（比值比：3.17；95%置信区间：1.39 - 7.22）以及有高尿酸血症家族史（比值比：2.56；95%置信区间：1.57 - 4.16）与高尿酸血症几率增加相关。
结论
2型糖尿病患者中高尿酸血症的发生率较高，对这些患者进行筛查将是有用的。
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