Westmead Hospital, Sydney, New South Wales, Australia.
Emerg Infect Dis. 2010 May;16(5):809-15. doi: 10.3201/eid1605.091136.
Influenza outbreaks during mass gatherings have been rarely described, and detailed virologic assessment is lacking. An influenza outbreak occurred during World Youth Day in Sydney, Australia, July 2008 (WYD2008). We assessed epidemiologic data and respiratory samples collected from attendees who sought treatment for influenza-like illness at emergency clinics in Sydney during this outbreak. Isolated influenza viruses were compared with seasonal influenza viruses from the 2008 influenza season. From 100 infected attendees, numerous strains were identified: oseltamivir-resistant influenza A (H1N1) viruses, oseltamivir-sensitive influenza A (H1N1) viruses, influenza A (H3N2) viruses, and strains from both influenza B lineages (B/Florida/4/2006-like and B/Malaysia/2506/2004-like). Novel viruses were introduced, and pre-WYD2008 seasonal viruses were amplified. Viruses isolated at mass gatherings can have substantial, complex, and unpredictable effects on community influenza activity. Greater flexibility by public health authorities and hospitals is required to appropriately manage and contain these outbreaks.
群体性集会期间的流感疫情鲜有描述，详细的病毒学评估也有所欠缺。2008 年 7 月（WYD2008）在澳大利亚悉尼举行的世界青年日期间发生了一起流感疫情。我们评估了在此次疫情期间，于悉尼各急诊诊所因流感样疾病就诊的与会者的流行病学数据和呼吸道样本。我们对分离出的流感病毒与 2008 年流感季节的季节性流感病毒进行了比较。从 100 名受感染的与会者中鉴定出了多种毒株：奥司他韦耐药性甲型（H1N1）病毒、奥司他韦敏感性甲型（H1N1）病毒、甲型（H3N2）病毒以及两种乙型流感谱系（B/Florida/4/2006 样和 B/Malaysia/2506/2004 样）的毒株。新型病毒被引入，且前世界青年日季节性病毒被放大。群体性集会期间分离出的病毒会对社区流感活动产生重大、复杂和不可预测的影响。公共卫生当局和医院需要更大的灵活性来适当管理和控制这些疫情。
