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与 COVID-19 缓解策略相关的聚集和群组导致的病例归因比例。

The population attributable fraction of cases due to gatherings and groups with relevance to COVID-19 mitigation strategies.

机构信息

Bristol Veterinary School, University of Bristol, Bristol BS40 5DU, UK.

Population Health Sciences, Bristol Medical School, Bristol, BS8 2BN, UK.

出版信息

Philos Trans R Soc Lond B Biol Sci. 2021 Jul 19;376(1829):20200273. doi: 10.1098/rstb.2020.0273. Epub 2021 May 31.

Abstract

Many countries have banned groups and gatherings as part of their response to the pandemic caused by the coronavirus, SARS-CoV-2. Although there are outbreak reports involving mass gatherings, the contribution to overall transmission is unknown. We used data from a survey of social contact behaviour that specifically asked about contact with groups to estimate the population attributable fraction (PAF) due to groups as the relative change in the basic reproduction number when groups are prevented. Groups of 50+ individuals accounted for 0.5% of reported contact events, and we estimate that the PAF due to groups of 50+ people is 5.4% (95% confidence interval 1.4%, 11.5%). The PAF due to groups of 20+ people is 18.9% (12.7%, 25.7%) and the PAF due to groups of 10+ is 25.2% (19.4%, 31.4%). Under normal circumstances with pre-COVID-19 contact patterns, large groups of individuals have a relatively small epidemiological impact; small- and medium-sized groups between 10 and 50 people have a larger impact on an epidemic. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK'.

摘要

许多国家已经禁止团体和集会,作为其应对冠状病毒(SARS-CoV-2)引发的大流行的一部分。尽管有涉及大规模集会的疫情报告,但对总体传播的贡献尚不清楚。我们使用了一项社会接触行为调查的数据,该调查专门询问了与团体的接触情况,以估计由于团体而导致的人群归因分数(PAF),即当团体被阻止时基本繁殖数的相对变化。50 人以上的团体占报告接触事件的 0.5%,我们估计 50 人以上团体的 PAF 为 5.4%(95%置信区间 1.4%,11.5%)。20 人以上团体的 PAF 为 18.9%(12.7%,25.7%),10 人以上团体的 PAF 为 25.2%(19.4%,31.4%)。在正常情况下,根据 COVID-19 之前的接触模式,大量人群对疫情的影响相对较小;而 10 至 50 人的中小团体对疫情的影响更大。本文是“塑造英国 COVID-19 大流行早期应对的建模”主题特刊的一部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c17d/8165584/bd5c8472cf39/rstb20200273f01.jpg

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