Department of Pathology and Laboratory Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
J Clin Pathol. 2010 May;63(5):410-5. doi: 10.1136/jcp.2009.071225.
Histopathological assessment of tumour grade and cell type is central to the management of endometrial carcinoma, guiding the extent of surgery and the use of adjuvant radiation therapy and chemotherapy. Endometrioid carcinomas are usually low grade but high-grade examples are encountered, and they have a significantly worse prognosis, similar to that of high-grade subtypes such as serous and clear cell carcinoma. This article reviews the various grading systems that have been proposed for use with endometrioid endometrial carcinoma, and discusses the recent progress in cell type assignment, including the use of immunohistochemistry as a diagnostic adjunct.
肿瘤分级和细胞类型的组织病理学评估是子宫内膜癌管理的核心，指导手术范围以及辅助放疗和化疗的应用。子宫内膜样癌通常为低级别，但也会出现高级别病例，其预后明显较差，与高级别亚型（如浆液性和透明细胞癌）相似。本文回顾了用于子宫内膜样子宫内膜癌的各种分级系统，并讨论了细胞类型分配的最新进展，包括免疫组织化学作为诊断辅助的应用。
