Maurer Hans H
Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany.
Clin Biochem. 2005 Apr;38(4):310-8. doi: 10.1016/j.clinbiochem.2005.01.014.
This paper reviews multi-analyte procedures for screening and quantification of drugs in blood, plasma, or serum using liquid chromatography coupled with a single stage or tandem mass spectrometer (LC-MS, LC-MS/MS). These procedures are relevant tools in clinical and forensic toxicology, and cover analysis of amphetamines, cocaine, hallucinogens, opioids, anesthetics, hypnotics, benzodiazepines, antidepressants, neuroleptics, antihistamines, sulfonylurea-type antidiabetics, beta-blockers, and other cardiac drugs. Basic information on the procedures is given in two tables and multi-analyte screening, identification, and quantification are illustrated in three figures. A critical discussion on the pros and cons of such LC-MS procedures is also included.
本文综述了使用液相色谱与单级或串联质谱仪（LC-MS、LC-MS/MS）联用技术对血液、血浆或血清中的药物进行筛查和定量的多分析物方法。这些方法是临床和法医毒理学中的相关工具，涵盖了苯丙胺类、可卡因、致幻剂、阿片类、麻醉剂、催眠药、苯二氮䓬类、抗抑郁药、抗精神病药、抗组胺药、磺酰脲类抗糖尿病药、β受体阻滞剂及其他心脏药物的分析。两个表格给出了这些方法的基本信息，三个图展示了多分析物筛查、鉴定和定量过程。还包括了对此类LC-MS方法优缺点的批判性讨论。
