Feldmeier H, Bienzle U, Jansen-Rosseck R, Kremsner P G, Wieland H, Dobos G, Schroeder S, Fengler-Dopp D, Peter H H
State Institute for Tropical Medicine, Berlin, Federal Republic of Germany.
Wien Klin Wochenschr. 1991;103(4):111-6.
It is still a matter of debate whether or not infection with Trichinella spiralis is followed by long lasting sequelae. A common source epidemic of trichinosis which occurred in Bitburg, FRG, in October 1982 gave us the opportunity of performing a controlled cohort study (171 patients and 51 controls). 145 patients and 44 controls completed the 3 year follow-up. Complaints persisted in 36% of patients aged less than 30 years and in 100% of patients aged greater than 50 years. Complaints in order of frequency were: muscular complaints 84%, ocular complaints 63%, cardiac complaints 48%, cephalgia 43%, neurological complaints 35%, gastrointestinal complaints 18%, m fatigue and weakness 18%, oedema 12% and fever less than 1%. IgG antibodies to T. spiralis were still present in all but 5 patients 3 years after infection. IgM antibodies were either low or absent. In our patients the frequency and pattern of complaints and the correlation to the specific antibody response provide evidence that trichinosis causes long-lasting disease. Yet, from our data we were unable to draw conclusions as to the causative pathophysiological mechanisms.
旋毛虫感染后是否会出现长期后遗症仍是一个有争议的问题。1982年10月在联邦德国比特堡发生的一起旋毛虫病共同源流行疫情，为我们提供了进行对照队列研究的机会（171例患者和51例对照）。145例患者和44例对照完成了3年随访。30岁以下患者中有36%的人仍有不适症状，50岁以上患者中100%仍有不适症状。按出现频率排序的不适症状有：肌肉不适84%、眼部不适63%、心脏不适48%、头痛43%、神经不适35%、胃肠道不适18%、疲劳和虚弱18%、水肿12%以及发热不到1%。感染3年后，除5例患者外，所有患者体内仍存在抗旋毛虫IgG抗体。IgM抗体水平低或不存在。在我们的患者中，不适症状的频率和模式以及与特异性抗体反应的相关性证明旋毛虫病会导致长期疾病。然而，从我们的数据中，我们无法得出关于致病病理生理机制的结论。
