University of Kansas Medical Center, 2330 Shawnee Mission Parkway, Suite 1104, Westwood, KS, 66205, USA.
Curr Oncol Rep. 2010 Mar;12(2):136-42. doi: 10.1007/s11912-010-0081-8.
Endocrine action of vitamin D and its role in calcium homeostasis and bone health are well known. The discovery that breast epithelial cells possess the same enzyme system as the kidney, permitting local manufacture of active vitamin D (1,25 dihydroxyvitamin D, or 1,25[(OH)(2)D]) from circulating precursors 25 hydroxyvitamin D [25(OH)D], has suggested an autocrine role for vitamin D, as well. Preclinical and ecologic studies support a role of vitamin D in prevention of breast cancer. Correlative study results of vitamin D intake or measurement of 25(OH)D, the long-lived precursor, are mixed but suggest a protective effect in premenopausal women. The large Women's Health Initiative failed to show any reduction in breast cancer incidence in postmenopausal women with a modest amount of vitamin D supplementation. Lack of effect, however, may have been related to trial design. A recent report also suggests that vitamin D may reduce breast cancer recurrence and mortality. Finally, vitamin D is being investigated as a means to reduce aromatase inhibitor-induced joint symptoms.
维生素 D 的内分泌作用及其在钙稳态和骨骼健康中的作用是众所周知的。人们发现，乳腺上皮细胞拥有与肾脏相同的酶系统，能够将循环前体 25 羟维生素 D [25(OH)D]转化为活性维生素 D（1,25 二羟维生素 D，或 1,25[(OH)(2)D]），这表明维生素 D 也具有自分泌作用。临床前和生态学研究支持维生素 D 在预防乳腺癌中的作用。关于维生素 D 摄入或 25(OH)D（半衰期较长的前体）测量的相关性研究结果不一，但提示其对绝经前妇女具有保护作用。大型妇女健康倡议（Women's Health Initiative）未能表明在绝经后妇女中，补充适量的维生素 D 会降低乳腺癌发病率。然而，没有效果可能与试验设计有关。最近的一份报告还表明，维生素 D 可能降低乳腺癌复发和死亡率。最后，人们正在研究维生素 D 是否可以减少芳香化酶抑制剂引起的关节症状。
