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8-杂芳基-2'-脱氧鸟苷衍生物的合成

Synthesis of 8-Heteroaryl-2'-deoxyguanosine Derivatives.

作者信息

Hobley Gerard, Gubala Vladimir, Rivera-Sánchez María Del C, Rivera José M

机构信息

Department of Chemistry, College of Natural Sciences, University of Puerto Rico, Río Piedras Campus, San Juan, Puerto Rico, PR-00931.

出版信息

Synlett. 2008 Jun 1;2008(10):1510-1514. doi: 10.1055/s-2007-1077795.

DOI:10.1055/s-2007-1077795
PMID:20428320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2860324/
Abstract

We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2'-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.

摘要

我们描述了使用铃木-宫浦或施蒂勒反应条件合成8-杂芳基-2'-脱氧鸟苷类似物的方法。未保护的和保护的8-溴-2'-脱氧鸟苷与市售的杂芳基硼酸或2-吡啶基溴的三烷基锡衍生物在有或没有微波辐射的情况下偶联，产率良好。

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