• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

褪黑素对一名盲童智障男孩非24小时睡眠-清醒周期的校正作用

Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy.

作者信息

Palm L, Blennow G, Wetterberg L

机构信息

Department of Pediatrics, University Hospital, Lund, Sweden.

出版信息

Ann Neurol. 1991 Mar;29(3):336-9. doi: 10.1002/ana.410290318.

DOI:10.1002/ana.410290318
PMID:2042950
Abstract

A 9-year-old, blind boy with severe mental retardation with a chronic sleep/wake disturbance had a circadian rhythm of 24.75 hours and an internal desynchronization of the endogenous rhythms. Treatment with oral melatonin given at 6 PM induced a regular sleep/wake pattern. Melatonin, in this patient, convincingly entrained the endogenous rhythm to the appropriate chronological 24-hour day.

摘要

一名9岁的盲童，患有严重智力障碍且伴有慢性睡眠/觉醒障碍，其昼夜节律为24.75小时，内源性节律存在内部不同步。下午6点口服褪黑素治疗诱导出了规律的睡眠/觉醒模式。在该患者中，褪黑素令人信服地使内源性节律与合适的24小时昼夜时间同步。

相似文献

1
Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy.褪黑素对一名盲童智障男孩非24小时睡眠-清醒周期的校正作用
Ann Neurol. 1991 Mar;29(3):336-9. doi: 10.1002/ana.410290318.
2
Entrainment of free-running circadian rhythms by melatonin in blind people.褪黑素对盲人自由运转的昼夜节律的调节作用。
N Engl J Med. 2000 Oct 12;343(15):1070-7. doi: 10.1056/NEJM200010123431503.
3
Amplitude reduction of plasma melatonin rhythm in association with an internal desynchronization in a subject with non-24-hour sleep-wake syndrome.非24小时睡眠-觉醒综合征患者血浆褪黑素节律的振幅降低与体内失同步有关。
Psychiatry Clin Neurosci. 1999 Apr;53(2):249-51. doi: 10.1046/j.1440-1819.1999.00535.x.
4
[Non-photic entrainment of human circadian clock--effects of forced sleep-wake schedule on the circadian rhythm in plasma melatonin].[人类生物钟的非光驱动同步——强制睡眠-清醒时间表对血浆褪黑素昼夜节律的影响]
Hokkaido Igaku Zasshi. 1996 May;71(3):403-22.
5
Case of a mentally retarded child with non-24 hour sleep-wake syndrome caused by deficiency of melatonin secretion.一例因褪黑素分泌不足导致非24小时睡眠-觉醒综合征的智力发育迟缓儿童病例。
Psychiatry Clin Neurosci. 2000 Jun;54(3):379-80. doi: 10.1046/j.1440-1819.2000.00723.x.
6
Promoting adjustment of the sleep-wake cycle by chronobiotics.通过时间生物学制剂促进睡眠-觉醒周期的调整。
Physiol Behav. 2007 Feb 28;90(2-3):294-300. doi: 10.1016/j.physbeh.2006.09.001. Epub 2006 Oct 20.
7
The effects of low-dose 0.5-mg melatonin on the free-running circadian rhythms of blind subjects.低剂量0.5毫克褪黑素对盲人自由运行昼夜节律的影响。
J Biol Rhythms. 2003 Oct;18(5):420-9. doi: 10.1177/0748730403256796.
8
Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with a regular 24-hour sleep-wake schedule.无光感知情况下的昼夜节律睡眠调节：一名睡眠-清醒周期为规律24小时的盲人的慢性非24小时昼夜节律睡眠障碍
Sleep. 1993 Jun;16(4):333-43. doi: 10.1093/sleep/16.4.333.
9
Melatonin: characteristics, concerns, and prospects.褪黑素：特性、问题与前景。
J Biol Rhythms. 2005 Aug;20(4):291-303. doi: 10.1177/0748730405277492.
10
Trials of bright light exposure and melatonin administration in a patient with non-24 hour sleep-wake syndrome.对一名非24小时睡眠-清醒综合征患者进行强光照射和褪黑素给药的试验。
Psychiatry Clin Neurosci. 1998 Apr;52(2):261-2. doi: 10.1111/j.1440-1819.1998.tb01064.x.

引用本文的文献

1
The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review.儿童和青少年自闭症谱系障碍中非器质性睡眠障碍口服褪黑素的药代动力学、剂量、剂型及疗效：一项系统评价
Children (Basel). 2025 May 16;12(5):648. doi: 10.3390/children12050648.
2
Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland.松果体钙化、褪黑素生成、衰老、相关健康后果和松果体的年轻化。
Molecules. 2018 Jan 31;23(2):301. doi: 10.3390/molecules23020301.
3
Circadian rhythm sleep disorders.
昼夜节律睡眠障碍。
Neurol Clin. 2012 Nov;30(4):1167-91. doi: 10.1016/j.ncl.2012.08.011.
4
Clinical uses of melatonin in pediatrics.褪黑素在儿科的临床应用。
Int J Pediatr. 2011;2011:892624. doi: 10.1155/2011/892624. Epub 2011 Jun 16.
5
Chronobiological disorders: current and prevalent conditions.昼夜节律紊乱：当前和普遍存在的状况。
J Occup Rehabil. 2010 Mar;20(1):21-32. doi: 10.1007/s10926-009-9213-0.
6
Visual impairment and circadian rhythm disorders.视力障碍与昼夜节律紊乱。
Dialogues Clin Neurosci. 2007;9(3):301-14. doi: 10.31887/DCNS.2007.9.3/slockley.
7
Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary.褪黑素补充剂用于患有基因决定的发育障碍的年轻人的严重和顽固性睡眠障碍：简短综述与评论。
J Med Genet. 2003 Nov;40(11):793-6. doi: 10.1136/jmg.40.11.793.
8
Circadian rhythm sleep disorders: pathophysiology and potential approaches to management.昼夜节律睡眠障碍：病理生理学及潜在的管理方法
CNS Drugs. 2001;15(4):311-28. doi: 10.2165/00023210-200115040-00005.
9
Effects of neonatal melatonin administration on the extra-hypothalamic regions in rat brains: effects on the serotonergic system.新生大鼠给予褪黑素对其脑内下丘脑外区域的影响：对血清素能系统的影响。
Neurochem Res. 2000 Jun;25(6):817-22. doi: 10.1023/a:1007517524179.
10
The melatonin rhythm: both a clock and a calendar.褪黑素节律：既是时钟又是日历。
Experientia. 1993 Aug 15;49(8):654-64. doi: 10.1007/BF01923947.