Cheng Chunwei, Pan Lili, Chen Yi, Song Hao, Qin Yong, Li Rongshi
Key Laboratory of Drug Targeting & Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
J Comb Chem. 2010 Jul 12;12(4):541-7. doi: 10.1021/cc100052j.
The first total synthesis of marine natural product, (+/-)-marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.
海洋天然产物（±）-海吡咯A的首次全合成已通过九步合成完成，总产率为30%。基于海吡咯设计并合成了一个小型聚焦文库。研究了化学合成范围，并在当前研究中开发了一种适用于文库合成的可靠化学方法。我们开发的方法使得基于结构新颖的海吡咯生成多种类似物成为可能，用于研究潜在的抗生素和抗癌活性。
