Zemtsovskaja Galina, Abina Jelena, Meigas Kalju, Pilt Kristjan, Viigimaa Margus
Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia.
Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia.
Arch Med Sci Atheroscler Dis. 2018 Jul 3;3:e99-e105. doi: 10.5114/amsad.2018.76919. eCollection 2018.
Associations found between pulse wave velocity (PWV) and cardiovascular risk factors (CVrF) are diverse. We aimed to evaluate whether differences in PWV and its associations with CVrF in a high cardiovascular risk population exist between genders and between the whole population (WHgr) and groups of apparently healthy (AHgr) and those of hypertensive, obese or diabetics (Rgr).
Pulse wave velocity measured by Arteriograph was investigated in 805 adults aged 20-65, randomly selected from the Tallinn Population Register.
Pulse wave velocity was the highest in Rgr and no differences were found between genders of the same group. In women of WHgr and AHgr age and SBP with addition of BMI and apolipoprotein B (ApoB) were associated with 54% and 48%, and without ApoB in Rgr with only 30% of PWV values. In men aged ≥ 50 of WHgr with elevated SBP odds ratios for increased PWV were 25.3 and 3.5, in Rgr 21.2 and 2.2, in those aged ≥ 50 AHgr 28.4. In women aged ≥ 50 of WHgr with elevated SBP and diabetes odds ratios were 5.5, 4.9 and 4.0, in Rgr with elevated SBP and diabetes 3.6 and 3.7, in those aged ≥ 50 AHgr 29.3.
The associations of ApoB and BMI with PWV and diabetes with elevated PWV indicative of increased aortic stiffness were unique for women. Aging and SBP were related to PWV even in AHgr, although age ≥ 50 years in Rgr women and normal SBP in AHgr were not associated with elevated PWV.
脉搏波速度（PWV）与心血管危险因素（CVrF）之间的关联多种多样。我们旨在评估在心血管高危人群中，PWV及其与CVrF的关联在性别之间以及在整个人群（WHgr）、看似健康人群组（AHgr）和高血压、肥胖或糖尿病患者组（Rgr）之间是否存在差异。
对从塔林人口登记册中随机选取的805名20 - 65岁成年人进行了动脉造影仪测量的脉搏波速度研究。
Rgr组的脉搏波速度最高，同一组内性别之间未发现差异。在WHgr组和AHgr组的女性中，年龄和收缩压（SBP）加上体重指数（BMI）和载脂蛋白B（ApoB）分别与54%和48%的PWV值相关，而在Rgr组中不考虑ApoB时仅与30%的PWV值相关。在WHgr组中，年龄≥50岁且SBP升高的男性，PWV升高的比值比分别为25.3和3.5，在Rgr组中为21.2和2.2，在年龄≥50岁的AHgr组中为28.4。在WHgr组中，年龄≥50岁且SBP升高和患有糖尿病的女性，比值比分别为5.5、4.9和4.0，在Rgr组中SBP升高和患有糖尿病的女性为3.6和3.7，在年龄≥50岁的AHgr组中为29.3。
ApoB和BMI与PWV的关联以及糖尿病与PWV升高（表明主动脉僵硬度增加）的关联在女性中是独特的。即使在AHgr组中，衰老和SBP也与PWV相关，尽管Rgr组中年龄≥50岁的女性和AHgr组中正常SBP与PWV升高无关。
