腊肠树花甲醇提取物的抗炎和镇痛活性。
Anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata DC flower.
机构信息
Department of Pharmacognosy and Ethnopharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India. carey
出版信息
J Ethnopharmacol. 2010 Jul 6;130(1):179-82. doi: 10.1016/j.jep.2010.04.023. Epub 2010 Apr 27.
ETHNOPHARMACOLOGICAL RELEVANCE
Kigelia pinnata DC is extensively used in Indian traditional medicine for several diseases including inflammatory and painful disorders.
AIM OF THE STUDY
The aim of the present study is to investigate the possible anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata flower (MKFL) to support the medicinal uses claimed by folklore practitioners.
MATERIALS AND METHODS
MKFL is evaluated for its anti-inflammatory activity in carrageenan-induced paw edema model in rats and analgesic activity in acetic acid-induced writhing, hot plate and formalin-induced paw licking models in mice.
RESULTS
MKFL exhibited a significant (P<0.01) anti-inflammatory and analgesic activities with the doses of 100, 200 and 400mg/kg b.w. in rats and mice respectively.
CONCLUSIONS
The results of the experimental study thus strongly support the traditional use of this plant for inflammatory and pain disorders.
民族药理学相关性
吊灯树 DC 在印度传统医学中被广泛用于多种疾病，包括炎症和疼痛疾病。
研究目的
本研究旨在研究吊灯树花（MKFL）甲醇提取物的可能抗炎和镇痛活性，以支持民间医生所声称的药用用途。
材料和方法
MKFL 在角叉菜胶诱导的大鼠足肿胀模型中评估其抗炎活性，在醋酸诱导的小鼠扭体、热板和福尔马林诱导的舔足模型中评估其镇痛活性。
结果
MKFL 分别以 100、200 和 400mg/kg b.w. 的剂量在大鼠和小鼠中表现出显著的（P<0.01）抗炎和镇痛活性。
结论
实验研究的结果强烈支持该植物用于炎症和疼痛疾病的传统用途。
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