Department of Microbial, Cellular and Molecular Biology, College of Natural and Computational Sciences, Addis Ababa University, Ethiopia.
Department of Biology, College of Natural and Computational Sciences, Arba Minch University, Ethiopia.
Ethiop J Health Sci. 2022 Jul;32(4):817-822. doi: 10.4314/ejhs.v32i4.19.
The objective of this study was to evaluate the anti-inflammatory activities and phytochemical composition of the leaves extracts of Boscia coriacea Graells and Uvaria leptocladon Oliv.
The powdered leaves of Boscia coriacea Graells and Uvaria leptocladon Oliv were extracted by maceration and soxhlet extraction methods. Anti-inflammatory activity of the leaves extracts of Boscia coriacea Graells and Uvaria leptocladon Oliv were evaluated using carrageenan-induced paw edema model. Standard methods were used for analysis of phytochemical composition of the leaves extracts of Boscia coriacea Graells and Uvaria leptocladon Oliv. Data analysis was done using one way analysis of variance.
U. leptocladon Oliv (200 mg/kg) and B. coriacea Graells (200 mg/kg) showed percent inhibition on mice paw edema of 86% and 75% after six hours of carrageenan injection, respectively. The ethanol fraction (100 mg/kg) of U. leptocladon Oliv showed the highest anti-inflammatory effect after six hours of carrageenan injection. The phytochemical analysis of the leaves extracts of B. coriacea and U. leptocladon revealed the presence of tannins, alkaloids, cardiac glycoside, flavonoids, phenols, quinones, and saponins.
The crude leaves extracts of B. coriacea Graells and U. leptocladon Oliv contain phytochemicals with anti-inflammatory activities.
本研究旨在评估 Boscia coriacea Graells 和 Uvaria leptocladon Oliv 叶提取物的抗炎活性和植物化学成分。
采用浸渍法和索氏提取法提取 Boscia coriacea Graells 和 Uvaria leptocladon Oliv 的叶粉末。采用角叉菜胶诱导的爪肿胀模型评价 Boscia coriacea Graells 和 Uvaria leptocladon Oliv 叶提取物的抗炎活性。采用标准方法分析 Boscia coriacea Graells 和 Uvaria leptocladon Oliv 叶提取物的植物化学成分。采用单因素方差分析进行数据分析。
U. leptocladon Oliv（200mg/kg）和 B. coriacea Graells（200mg/kg）在角叉菜胶注射后 6 小时分别对小鼠爪肿胀的抑制率为 86%和 75%。U. leptocladon Oliv 的乙醇部分（100mg/kg）在角叉菜胶注射后 6 小时表现出最高的抗炎作用。B. coriacea 和 U. leptocladon 的叶提取物的植物化学成分分析表明存在单宁、生物碱、强心苷、类黄酮、酚类、醌类和皂苷。
B. coriacea Graells 和 U. leptocladon Oliv 的粗叶提取物含有具有抗炎活性的植物化学成分。
