Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, s-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
Eur J Clin Microbiol Infect Dis. 2010 Jul;29(7):755-63. doi: 10.1007/s10096-010-0946-7. Epub 2010 May 2.
Invasive fungal infections are relatively common opportunistic infections in immunocompromised patients and are still associated with a high mortality rate. Furthermore, these infections are often complicated by resistance or refractoriness to current antimicrobial agents. Therefore, an urgent need exists for new therapeutic strategies based on the identification of new microbial targets and novel antimicrobial agents. One such hypothetical therapeutic strategy may involve the use of mycoviruses that are able to selectively infect fungi. Current knowledge of mycoviruses of human pathogenic fungi and the scope for using (recombinant) mycoviruses as future biological control agents are reviewed here.
侵袭性真菌感染是免疫功能低下患者中较为常见的机会性感染，仍与高死亡率相关。此外，这些感染通常因对现有抗菌药物的耐药性或抗药性而变得复杂。因此，迫切需要基于新的微生物靶点和新型抗菌药物的识别来制定新的治疗策略。一种这样的假设性治疗策略可能涉及使用能够选择性感染真菌的真菌病毒。本文综述了人类致病性真菌的真菌病毒的现有知识，以及作为未来生物防治剂使用（重组）真菌病毒的范围。
