Division of Biomedical Sciences, University of California, Riverside, California 92521, USA.
J Clin Invest. 2010 May;120(5):1368-79. doi: 10.1172/JCI41911. Epub 2010 May 3.
The CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct anatomical sites (i.e., meninges, cerebrospinal fluid, and parenchyma) associated with the CNS can also be deleterious. Therefore, control of lymphocyte entry and migration within the brain is vital to regulate protective and pathological responses. In this review, several recent advances are highlighted that provide new insights into the processes that regulate leukocyte access to, and movement within, the brain.
中枢神经系统(CNS)是一个免疫特惠环境,但多种病原体的局部控制依赖于免疫细胞进入和在该部位发挥作用的能力。然而,与中枢神经系统相关的不同解剖部位(即脑膜、脑脊液和实质)的炎症也可能是有害的。因此,控制淋巴细胞进入和在大脑内迁移对于调节保护性和病理性反应至关重要。在这篇综述中,强调了几个最近的进展,这些进展为调节白细胞进入和在大脑内运动的过程提供了新的见解。