通过羟醛缩合与二苯乙醇酸重排相结合，由2,3 - 二酮酯不对称合成1H - 吡咯 - 3(2H)-酮
Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement.
作者信息
Sha Qiang, Arman Hadi, Doyle Michael P
机构信息
School of Chemical Engineering, Nanjing University of Science and Technology, Xiao Ling Wei 200, Nanjing 210094, P. R. China and Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, USA.
Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, USA.
出版信息
Chem Commun (Camb). 2016 Jan 4;52(1):108-11. doi: 10.1039/c5cc07780j.
Abstract
An efficient two-step protocol for the asymmetric synthesis of 1H-pyrrol-3(2H)-one derivatives in 99% ee from conveniently accessed 2,3-diketoesters has been developed.
摘要
已经开发出一种高效的两步法方案，可从易于获得的2,3-二酮酯以99%的对映体过量（ee）不对称合成1H-吡咯-3(2H)-酮衍生物。
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