Department of Community Health and Psychiatry, University of the West Indies, Mona, Kingston, Jamaica.
Cancer Causes Control. 2010 Dec;21(12):2249-57. doi: 10.1007/s10552-010-9648-9. Epub 2010 Oct 6.
We evaluated the relationship of spot urinary concentrations of phytoestrogens with total prostate cancer and tumor grade in a hospital-based case-control study in Jamaica. Urine samples were analyzed for genistein, daidzein, equol (isoflavones), and enterolactone (lignan) among newly diagnosed cases (n = 175) and controls (n = 194). Urinary concentrations of enterolactone (lignan) were higher among cases. There were no significant differences in median concentrations of isoflavone excretion. Compared with non-producers of equol (reference tertile), men who produced equol were at decreased risk of total prostate cancer (tertile 2: OR, 0.42; CI, 0.23-0.75) (tertile 3: OR, 0.48; CI, 0.26-0.87) (p (trend), 0.020) and high-grade disease (tertile 2: OR, 0.31; CI, 0.15-0.61) (tertile 3: OR, 0.29; CI, 0.13-0.60) (p (trend), 0.001). Higher concentrations of enterolactone were positively related to total prostate cancer (OR, 1.85; CI, 1.01-3.44; p (trend), 0.027) as well as high-grade disease (OR, 2.46; CI, 1.11-5.46; p (trend), 0.023). There were no associations between urinary excretion of genistein and daidzein with risk of prostate cancer. Producers of equol (isoflavone) may be at reduced risk of total- and high-grade prostate cancer whereas enterolactone may increase the likelihood of disease.
我们在牙买加的一项基于医院的病例对照研究中评估了植物雌激素的尿液浓度与前列腺癌总发病率和肿瘤分级的关系。在新诊断的病例（n=175）和对照组（n=194）中分析了尿液样本中的染料木黄酮、大豆苷元、结合物（异黄酮）和肠内乳糖（木脂素）。病例组的肠内乳糖（木脂素）浓度较高。异黄酮排泄的中位数浓度没有显著差异。与非结合物（参考三分位数）的男性相比，能产生结合物的男性患前列腺癌总发病率降低（三分位数 2：OR，0.42；CI，0.23-0.75）（三分位数 3：OR，0.48；CI，0.26-0.87）（p（趋势），0.020）和高级别疾病（三分位数 2：OR，0.31；CI，0.15-0.61）（三分位数 3：OR，0.29；CI，0.13-0.60）（p（趋势），0.001）。肠内乳糖浓度较高与前列腺癌总发病率呈正相关（OR，1.85；CI，1.01-3.44；p（趋势），0.027）以及高级别疾病（OR，2.46；CI，1.11-5.46；p（趋势），0.023）。染料木黄酮和大豆苷元的尿液排泄与前列腺癌风险无关。结合物（异黄酮）的产生可能会降低前列腺癌总发病率和高级别发病率的风险，而肠内乳糖可能会增加疾病的可能性。
