钯/铜催化磷翁偶联促进互变异构杂环化合物与炔烃的直接脱水交叉偶联。
Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling.
机构信息
Johnson & Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.
出版信息
Chem Commun (Camb). 2010 Feb 28;46(8):1347-9. doi: 10.1039/b917777a. Epub 2010 Jan 11.
DOI:10.1039/b917777a
PMID:20449299
Abstract
The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes has been achieved via C-H/C-OH bond activations with direct C(sp(2))-C(sp) bond formation, which is in line with ideal synthesis using readily available materials.
摘要
通过 C-H/C-OH 键的活化以及直接的 C(sp(2))-C(sp) 键形成，实现了首例可互变异构的杂环与炔烃的化学选择性直接脱水交叉偶联反应，符合使用易得原料的理想合成。
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