[粗齿碘树乙醇提取物水溶性部分的成分]
[Constituents from a water-soluble portion of ethanolic extract of Iodes cirrhosa].
作者信息
Gan Maoluo, Zhu Chenggeni, Zhang Yanling, Zi Jiachen, Song Weixia, Yang Yongchun, Shi Jiangong
机构信息
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(4):456-67.
OBJECTIVE
To investigate chemical constituents of Iodes cirrhosa.
METHOD
Constituents were isolated by using a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and C-18, as well as reversed-phase HPLC. Structures of the isolates were identified by spectroscopic and chemical methods.
RESULT
Twenty-four compounds were obtained from a H2O-soluble portion of an ethanolic extract of the root of lodes cirrhosa Turcz. Structures of the isolates were identified as (-)-(7R,8S,7'E) -4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8,4'-oxyneolign-7'-ene-9'-O-beta-D-glucopyra-noside (1), (-)-(7S,8S,7'E)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8,4'-oxyneolign-7'-ene-9'-O-beta-D-glucopyranoside(2), (+)-(7S,8S)-syringylglycerol 8-O-beta-D-glucopyranoside (3), (+)-(7S, 8S)-guaiacylglycerol 8-O-P-D-glucopyranoside (4), (-)-(7S, 8S)-4,7,9, 9'-tetrahydroxy-3,3'-dimethoxy-8,4'-oxyneolignan-7-O-beta-D-glucopyranoside (5),(-)-alaschanisoside A (6), (-)-(2R)-1-O-beta-D-glucopyranosyl-2-(2-methoxy-4-[1-(E)-propen-3-ol] phenoxyl propane-3-ol(7), (-)-(2R)-1-O-beta-D-glucopyranosyl-2-{2,6-dimethoxy-4-[1-(E)-propen-3-ol] phenoxyl} propane-3-ol(8), (-)-liriodendrin(9), (-)-(7S, 8R)-guaiacylglycerol 9-O-beta-D-glucopyranoside(10), (-)-(7R, 8R)-guaiacylglycerol 9-O-beta-D-glucopyranoside(11),(-)-(7R,8R)-syringylglycerol 9-O-beta-D-glucopyranoside(12), (-)-(7R,8R)-guaiacylglycerol 7-O-beta-D-glucopyranoside(13), (-)-11,13-dihydrodeacylcynaropicrin 3-O-beta-D-glucopyranoside(14), (-)-sweroside (15), (-)-2-hydroxy-5-(2-hydroxyethyl) phenyl beta-D-glucopyranoside(16), (-)-(1'R)-1'-(3-hydroxy-4-methoxyphenyl) ethane-1',2'-diol-3-O-beta-D-glucopyranoside(17), (-)-tachioside(18), (-)-3,5-dimethoxy-4-hydroxyphenyl beta-D-glucopyranoside(19), (-)-3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone-3-O-beta-D-glucopy ranoside(20), (-)-2-methoxy4-(1-propionyl) phenyl beta-D-glucopyranoside(21), (-)-4-propionyl-3, 5-dimethoxyphenyl beta-D-glucopyranoside(22), erigeside C(23), and scopoletin beta-D-xylopyranosyl-(1-->6)-beta-D-glucopyranoside(24).
CONCLUSION
Compounds 1-24 were obtained from the genus for the first time.
目的
研究毛叶碘泡虫的化学成分。
方法
采用多种色谱技术相结合的方法进行成分分离，包括硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱、C - 18柱色谱以及反相高效液相色谱。通过光谱和化学方法鉴定分离物的结构。
结果
从毛叶碘泡虫Turcz.根乙醇提取物的水溶性部分获得了24种化合物。分离物的结构被鉴定为(-)-(7R,8S,7'E)-4,7,9,9'-四羟基-3,3'-二甲氧基-8,4'-氧新木脂素-7'-烯-9'-O-β-D-吡喃葡萄糖苷(1)、(-)-(7S,8S,7'E)-4,7,9,9'-四羟基-3,3'-二甲氧基-8,4'-氧新木脂素-7'-烯-9'-O-β-D-吡喃葡萄糖苷(2)、(+)-(7S,8S)-丁香甘油8-O-β-D-吡喃葡萄糖苷(3)、(+)-(7S,8S)-愈创木酚甘油8-O-β-D-吡喃葡萄糖苷(4)、(-)-(7S,8S)-4,7,9,9'-四羟基-3,3'-二甲氧基-8,4'-氧新木脂素-7-O-β-D-吡喃葡萄糖苷(5)、(-)-阿拉善糖苷A(6)、(-)-(2R)-1-O-β-D-吡喃葡萄糖基-2-(2-甲氧基-4-[1-(E)-丙烯-3-醇]苯氧基)丙烷-3-醇(7)、(-)-(2R)-1-O-β-D-吡喃葡萄糖基-2-{2,6-二甲氧基-4-[1-(E)-丙烯-3-醇]苯氧基}丙烷-3-醇(8)、(-)-鹅掌楸苷(9)、(-)-(7S,8R)-愈创木酚甘油9-O-β-D-吡喃葡萄糖苷(10)、(-)-(7R,8R)-愈创木酚甘油9-O-β-D-吡喃葡萄糖苷(11)、(-)-(7R,8R)-丁香甘油9-O-β-D-吡喃葡萄糖苷(12)、(-)-(7R,8R)-愈创木酚甘油7-O-β-D-吡喃葡萄糖苷(13)、(-)-11,13-二氢去酰基矢车菊苦素3-O-β-D-吡喃葡萄糖苷(14)、(-)-獐牙菜苷(15)、(-)-2-羟基-5-(2-羟乙基)苯基β-D-吡喃葡萄糖苷(16)、(-)-(1'R)-1'-(3-羟基-4-甲氧基苯基)乙烷-1',2'-二醇-3-O-β-D-吡喃葡萄糖苷(17)、(-)-龙胆碱(18)、(-)-3,5-二甲氧基-4-羟基苯基β-D-吡喃葡萄糖苷(19)、(-)-3-羟基-1-(4-羟基-3-甲氧基苯基)-1-丙酮-3-O-β-D-吡喃葡萄糖苷(20)、(-)-2-甲氧基-4-(1-丙酰基)苯基β-D-吡喃葡萄糖苷(21)、(-)-4-丙酰基-3,5-二甲氧基苯基β-D-吡喃葡萄糖苷(22)、毛大丁草苷C(23)和东莨菪素β-D-木糖基-(1→6)-β-D-吡喃葡萄糖苷(24)。
结论
化合物1 - 24首次从该属植物中获得。
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