Jiang Hai, Yang Liu, Xing Xu-Dong, Yan Mei-Ling, Guo Xin-Yue, Su Xiao-Lin, Sun Yan-Ping, Yang Bing-You, Wang Qiu-Hong, Kuang Hai-Xue
Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang Key Laboratory of Traditional of Chinese Medicine and Natural Medicine Pharmacodynamic Material Bases, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zhongguo Zhong Yao Za Zhi. 2018 May;43(10):2097-2103. doi: 10.19540/j.cnki.cjcmm.20180123.003.
This project is to investigate lignans from the dried fruits of Xanthium sibiricum (Xanthii Fructus). The chemical constituents were extract by 70% ethanol and isolated by silica gel, ODS, Sephadex LH-20, MCI column chromatography. Based on comparison of their spectral data with those reported in literature, they were elucidated as (-)-pinoresinol (1), balanophonin A (2), diospyrosin (3), dehydrodiconiferyl alcohol (4), 2-(4-hydroxy-3-methoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-3-oxo-1-propanol (5), (-)-simulanol (6), (-)-7R,8S-dehydrodiconiferyl alcohol (7), chushizisin E (8), dihydrodehydrodiconiferyl alcohol (9), 7R,8S-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (10), erythro-1,2-bis(4-hydroxy-3-methoxyphenyl)-1,3-propanediol (11), leptolepisol D (12), 8-O-4' neolignan 4-O-β-glucopyranoside (13), (-)-1-O-β-D-glucopyranosyl-2-{2-methoxy-4-[1-(E)-propen-3-ol]phenoxyl}-propane-3-ol(14), 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1,2,3-trihydroxypropyl)-2-methoxy]-phenoxy-1,3-propandiol (15), threo-dihydroxy dehydrodiconiferyl alcohol (16), (-)-(2R)-1-O-β-D-glucopyranosyl-2-{2-methoxy-4-[(E)-formylviny1]phenoxyl} propane-3-ol (17). Compound 2-17 were isolated from the genus Xanthium for the first time. Compound 1 were isolated form Xanthii Fructus for the first time.
本项目旨在研究苍耳（苍耳子）干燥果实中的木脂素。其化学成分用70%乙醇提取，通过硅胶柱色谱、ODS柱色谱、葡聚糖凝胶LH - 20柱色谱、MCI柱色谱进行分离。通过将它们的光谱数据与文献报道的数据进行比较，鉴定出它们分别为（-）-松脂醇（1）、巴兰诺芬宁A（2）、柿叶素（3）、脱氢二松柏醇（4）、2 - （4 - 羟基 - 3 - 甲氧基苯基）- 3 - （2 - 羟基 - 5 - 甲氧基苯基）- 3 - 氧代 - 1 - 丙醇（5）、（-）-西木兰醇（6）、（-）-7R，8S - 脱氢二松柏醇（7）、川续断苷E（8）、二氢脱氢二松柏醇（9）、7R，8S - 二氢脱氢二松柏醇4 - O - β - D - 吡喃葡萄糖苷（10）、赤式 - 1，2 - 双（4 - 羟基 - 3 - 甲氧基苯基）- 1，3 - 丙二醇（11）、细鳞苔醇D（12）、8 - O - 4'新木脂素4 - O - β - 葡萄糖苷（13）、（-）-1 - O - β - D - 吡喃葡萄糖基 - 2 - {2 - 甲氧基 - 4 - [1 - （E）- 丙烯 - 3 - 醇]苯氧基}-丙烷 - 3 - 醇（14）、1 - （4 - 羟基 - 3 - 甲氧基）-苯基 - 2 - [4 - （1，2，3 - 三羟基丙基）- 2 - 甲氧基]-苯氧基 - 1，3 - 丙二醇（15）、苏式 - 二羟基脱氢二松柏醇（16）、（-）-（2R）-1 - O - β - D - 吡喃葡萄糖基 - 2 - {2 - 甲氧基 - 4 - [（E）- 甲酰乙烯基]苯氧基}丙烷 - 3 - 醇（17）。化合物2 - 17首次从苍耳属植物中分离得到。化合物1首次从苍耳子中分离得到。
