Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Physiology, Medical Faculty, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Pharm Biol. 2020 Dec;58(1):447-453. doi: 10.1080/13880209.2020.1762669.
There are numerous pharmacological activities for and its bioactive constituent, rutin, on learning and memory. This study aimed to examine the effect of and rutin on memory in rats. In this study animals were treated with the hydroalcholic extract of and rutin by IP injection for 10 days. Behavioural and biochemical tests as well as HPLC analysis and antioxidant activity of extract have been evaluated. extract and rutin significantly increased learning and improved spatial memory, as well as secondary latency; moreover, there were significant increases in the serum and brain antioxidant capacity as well as the level of TBARS in serum and brain tissues. Results also showed that has significant DPPH radical scavenging effect (IC: 159.17 ± 1.56 μg/mL). The HPLC analysis of extract showed that caffeic acid (19.92 ± 0.01), rutin (40.15 ± 0.01), and apigenin (0.84 ± 0.01) mg/g of dry extract are the main components of the extract. Regarding the effects of . extract and rutin on animal brain cells, memory function, and learning, additional studies, including clinical trials, might be beneficial in producing natural supplementary drugs from this herb.
有许多药理学活动针对 和其生物活性成分芦丁，以学习和记忆。本研究旨在研究 和芦丁对大鼠记忆的影响。在这项研究中，动物通过腹腔注射接受 的水醇提取物和芦丁治疗 10 天。评估了行为和生化测试以及提取物的 HPLC 分析和抗氧化活性。 提取物和芦丁显著提高了学习能力，改善了空间记忆和次要潜伏期；此外，血清和大脑的抗氧化能力以及血清和脑组织中 TBARS 的水平显著增加。结果还表明， 具有显著的 DPPH 自由基清除作用（IC：159.17±1.56μg/mL）。提取物的 HPLC 分析表明，该提取物中的主要成分是咖啡酸（19.92±0.01）、芦丁（40.15±0.01）和芹菜素（0.84±0.01）mg/g 干提取物。关于 的影响 提取物和芦丁对动物脑细胞、记忆功能和学习的影响，包括临床试验在内的进一步研究可能有助于从这种草药中产生天然补充药物。
