迷走神经刺激及其在引发胃泌素释放而非从离体灌注犬胃释放胰高血糖素方面的作用。
Vagal stimulation and its role in eliciting gastrin but not glucagon release from the isolated perfused dog stomach.
作者信息
Lefebvre P J, Luyckx A S, Brassinne A H
出版信息
Gut. 1978 Mar;19(3):185-8. doi: 10.1136/gut.19.3.185.
Abstract
Electrical stimulation (10 V, 10 Hz, 3 min) of both dorsal and ventral vagal trunks of the isolated canine stomach perfused with whole blood induced strong gastric contractions, transient release of cyclic GMP and marked release of gastrin. No gastric-glucagon release was elicited either at 'normal' (4.8 +/- 0.1 mmol/l) or at low (1.5 +/- 0.1 mmol/l) concentrations of blood glucose. It is concluded that, in conditions effective for the stimulation of gastrin release, electrical stimulation of the vagus nerves does not stimulate glucagon release from the isolated perfused dog stomach. Thus one of the well-accepted mechanisms controlling pancreatic-glucagon secretion, vagal stimulation, is ineffective on gastric-glucagon release.
摘要
对用全血灌注的离体犬胃的背侧和腹侧迷走神经干进行电刺激（10伏，10赫兹，3分钟），可诱发强烈的胃收缩、环磷酸鸟苷的短暂释放和胃泌素的显著释放。无论是在“正常”（4.8±0.1毫摩尔/升）还是低（1.5±0.1毫摩尔/升）血糖浓度下，均未引发胃胰高血糖素释放。得出的结论是，在对胃泌素释放有效的条件下，电刺激迷走神经不会刺激离体灌注犬胃释放胰高血糖素。因此，控制胰腺胰高血糖素分泌的一个公认机制，即迷走神经刺激，对胃胰高血糖素释放无效。
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