日本炎症性肠病患儿生长障碍的评估

Shono Tetsuo, Kato Mayuko, Aoyagi Yo, Haruna Hidenori, Fujii Tohru, Kudo Takahiro, Ohtsuka Yoshikazu, Shimizu Toshiaki

Department of Pediatrics, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

Int J Pediatr. 2010;2010:958915. doi: 10.1155/2010/958915. Epub 2010 May 5.

In Japan, there is as yet no report on growth retardation in children with IBD. We therefore investigated the cause of growth retardation in Japanese children with IBD. We investigated the height, body weight, serum levels of albumin, IGF-I, CRP, and cytokines, and the amount of corticosteroid administered in children with Crohn's disease (CD, n = 15) and ulcerative colitis (UC, n = 18). Our results suggest that growth retardation is already present before the initial visit in children with CD, and chronic inflammation may be responsible this growth disturbance. Moreover, the amount of PSL used may contribute to growth retardation by decreasing the serum levels of IGF-I in children with IBD.

在日本，尚无关于炎症性肠病（IBD）患儿生长发育迟缓的报道。因此，我们对日本IBD患儿生长发育迟缓的原因进行了调查。我们调查了克罗恩病（CD，n = 15）和溃疡性结肠炎（UC，n = 18）患儿的身高、体重、血清白蛋白、胰岛素样生长因子-I（IGF-I）、C反应蛋白（CRP）及细胞因子水平，以及皮质类固醇的使用量。我们的结果表明，CD患儿在初次就诊前就已出现生长发育迟缓，慢性炎症可能是这种生长障碍的原因。此外，泼尼松龙（PSL）的使用量可能通过降低IBD患儿的血清IGF-I水平导致生长发育迟缓。