认知衰老对于理解痴呆症的重要性。
The importance of cognitive aging for understanding dementia.
作者信息
Singh-Manoux Archana, Kivimäki Mika
机构信息
INSERM, U1018 Centre for Research in Epidemiology & Population Health Hôpital Paul Brousse, Bâtiment 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France.
出版信息
Age (Dordr). 2010 Dec;32(4):509-12. doi: 10.1007/s11357-010-9147-7. Epub 2010 May 8.
Abstract
A third of those over 80 years of age are likely to have dementia, the lack of a cure requires efforts directed at prevention and delaying the age of onset. We argue here for the importance of understanding the cognitive ageing process, seen as the decline in various cognitive functions from adulthood to old age. The impact of age on cognitive function is heterogeneous and the identification of risk factors associated with adverse cognitive ageing profiles would allow well-targeted interventions, behavioural or pharmacological, to delay and reduce the population burden of dementia. A shift away from binary outcomes such as dementia assessed at one point in time in elderly populations to research on cognitive ageing using repeated measures of cognitive function and starting earlier in the life course would allow the sources of variability in ageing to be better understood.
摘要
80岁以上的人群中有三分之一可能患有痴呆症，由于缺乏治愈方法，需要致力于预防和延缓发病年龄。我们在此强调理解认知衰老过程的重要性，认知衰老过程被视为从成年到老年各种认知功能的衰退。年龄对认知功能的影响是异质性的，识别与不良认知衰老特征相关的风险因素将有助于进行有针对性的行为或药物干预，以延缓和减轻痴呆症的人群负担。从老年人群中某一时刻评估的痴呆症等二元结果，转向使用认知功能重复测量并在生命历程中更早开始的认知衰老研究，将有助于更好地理解衰老过程中的变异性来源。
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