Zeiger R S, Heller S, Mellon M H, Wald J, Falkoff R, Schatz M
Department of Allergy-Immunology, Kaiser-Permanente Medical Center, San Diego, Calif.
J Allergy Clin Immunol. 1991 Jun;87(6):1160-8. doi: 10.1016/0091-6749(91)92162-t.
Facilitated asthma-specialist care delivered by allergists was compared to generalist care on the rate of relapse of asthma emergency room (ER) visits and hospitalizations and on asthma control in a prospective, controlled study of San Diego Kaiser Health Plan members with asthma. Subjects with asthma between the ages of 6 and 59 years presenting for acute ER care for asthma were systematically assigned by alternating, consecutively, the day of their ER visit to receive either (1) facilitated referral to an asthma specialist within the allergy department and concomitant comprehensive ongoing asthma care (intervention group, n = 149) or (2) continued outpatient management from generalist physicians (control group, n = 160). The course of their asthma was evaluated blindly during the subsequent 6 months by review of medical records, initial and follow-up questionnaires, and spirometry. Compared to the control group, the intervention group noted (1) a 75% reduction in the number of, and percent of, subjects with asthma awakenings per night (p less than or equal to 0.0001), (2) an almost 50% reduction in asthma ER relapses (p = 0.017) resulting from a reduction in the frequency of multiple relapse (p = 0.005), and (3) a greater use of inhaled corticosteroids (p less than 0.00001) and cromolyn (p = 0.002). Thus, facilitated referral of subjects with asthma to specialists in asthma therapy after acute ER therapy appears to reduce asthma ER relapses and to improve asthma outcome.
在一项针对圣地亚哥凯撒医疗计划中患有哮喘的成员的前瞻性对照研究中,对过敏症专科医生提供的便捷哮喘专科护理与普通医生护理在哮喘急诊室(ER)就诊和住院复发率以及哮喘控制方面进行了比较。年龄在6至59岁之间因哮喘急性ER护理就诊的哮喘患者,根据其ER就诊日期交替、连续地系统分配,以接受以下两种治疗之一:(1)转介至过敏科内的哮喘专科医生并同时接受全面的持续哮喘护理(干预组,n = 149);或(2)由普通医生继续进行门诊管理(对照组,n = 160)。在随后的6个月中,通过审查病历、初始和随访问卷以及肺活量测定法对他们的哮喘病程进行了盲法评估。与对照组相比,干预组发现:(1)每晚哮喘发作的患者数量和百分比减少了75%(p≤0.0001);(2)由于多次复发频率降低(p = 0.005),哮喘ER复发率几乎降低了50%(p = 0.017);(3)吸入性糖皮质激素(p<0.00001)和色甘酸钠(p = 0.002)的使用量增加。因此,在急性ER治疗后将哮喘患者便捷地转介至哮喘治疗专科医生似乎可以减少哮喘ER复发并改善哮喘治疗效果。