载脂蛋白 E 等位基因在帕金森病发病中的作用。挪威 ParkWest 研究。
The role of APOE alleles in incident Parkinson's disease. The Norwegian ParkWest Study.
机构信息
The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.
出版信息
Acta Neurol Scand. 2010 Dec;122(6):438-41. doi: 10.1111/j.1600-0404.2010.01362.x.
OBJECTIVES
Apolipoprotein E (APOE) gene alleles have been associated with various neurodegenerative disorders. However, there have been conflicting reports on associations between APOE alleles and Parkinson's disease (PD) and age at onset in PD. There exist no data on APOE alleles in an unselected cohort of patients with incident PD.
PATIENTS AND METHODS
To determine the role of APOE alleles in PD and age of onset in PD at time of diagnosis, 203 patients with incident PD and 187 healthy control subjects from Western and Southern Norway were investigated according to their APOE allele status.
RESULTS
No association was observed between any APOE alleles and susceptibility to PD or age at onset in PD.
CONCLUSION
In our cohort of unselected, incident PD patients APOE alleles do not seem to play a role for development of PD. Prospective, long-term follow-up may still reveal associations between APOE alleles and clinical and neuropsychological progression in PD.
目的
载脂蛋白 E（APOE）基因等位基因与各种神经退行性疾病有关。然而，APOE 等位基因与帕金森病（PD）和 PD 发病时的发病年龄之间的关联存在相互矛盾的报告。在未经选择的 PD 新发患者队列中，不存在关于 APOE 等位基因的数据。
患者和方法
为了确定 APOE 等位基因在 PD 中的作用和 PD 发病时的发病年龄，根据 APOE 等位基因状态，对来自挪威西部和南部的 203 名 PD 新发患者和 187 名健康对照者进行了研究。
结果
未观察到任何 APOE 等位基因与 PD 的易感性或 PD 发病时的发病年龄之间存在关联。
结论
在我们未经选择的 PD 新发患者队列中，APOE 等位基因似乎对 PD 的发病没有作用。前瞻性、长期随访可能仍然会揭示 APOE 等位基因与 PD 的临床和神经心理学进展之间的关联。
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