Ghent University, Faculty of Medicine, Department of Oto-rhino-laryngology and Logopaedic-audiologic Sciences, De Pintelaan 185, B - 9000 Ghent, Belgium.
Clin Neurophysiol. 2010 Aug;121(8):1267-78. doi: 10.1016/j.clinph.2010.03.008. Epub 2010 Apr 24.
The present study aimed at establishing clinically efficient stopping criteria for a multiple 80-Hz auditory steady-state response (ASSR) system.
In Experiment 1, data of 31 normal-hearing subjects were analyzed off-line to propose stopping rules. Consequently, ASSR recordings will be stopped when (1) all 8 responses reach significance and significance can be maintained for 8 consecutive sweeps; or (2) the mean noise levels were 4nV (if p-values were between 0.05 and 0.1, measurements were extended once by 8 sweeps); or (3) a maximum amount of 48 sweeps was attained; whichever occurred first. In Experiment 2, these stopping criteria were applied on 10 normal hearing and 10 hearing-impaired adults to assess the efficiency.
The application of these stopping rules resulted in ASSR threshold values that were comparable to other ASSR research. Furthermore, preliminary analysis of the response and noise amplitudes demonstrated slightly higher values for hearing impaired than normal-hearing subjects.
The proposed stopping rules can be used in adults to determine accurate ASSR thresholds within a time-frame of about 1h.
The use of these a priori stopping criteria might assist the clinician in their decision to terminate ASSR recordings.
本研究旨在为 80-Hz 多频听觉稳态反应（ASSR）系统建立临床有效的停止标准。
在实验 1 中，对 31 名正常听力受试者的离线数据进行分析，提出停止规则。因此，当（1）所有 8 个反应均达到显著水平，且显著水平可维持 8 个连续扫频；或（2）平均噪声水平为 4nV（如果 p 值在 0.05 到 0.1 之间，则测量值通过 8 个扫频延长一次）；或（3）达到最大 48 个扫频时，首先满足任何一个条件，ASSR 记录就会停止。在实验 2 中，这些停止标准应用于 10 名正常听力和 10 名听力障碍成年人，以评估其效率。
这些停止规则的应用得出的 ASSR 阈值与其他 ASSR 研究相当。此外，对反应和噪声幅度的初步分析表明，听力障碍受试者的数值略高于正常听力受试者。
所提出的停止规则可用于成年人在大约 1 小时的时间框架内确定准确的 ASSR 阈值。
这些先验停止标准的使用可能有助于临床医生决定终止 ASSR 记录。
