Audiology and Deafness Research Group, School of Psychological Sciences, The University of Manchester, Manchester, United Kingdom.
Ear Hear. 2012 Mar-Apr;33(2):267-78. doi: 10.1097/AUD.0b013e318230bba0.
The aim of this study was to assess the between-session repeatability of auditory steady state response (ASSR) amplitudes and to examine F ratio response detection parameters.
Suprathreshold ASSRs were recorded from 20 normal-hearing and 10 hearing-impaired subjects. Amplitudes and latencies were recorded in two test sessions conducted on separate days.
The repeatability coefficients (limits of expected variation in repeat measurements) for amplitude and latency of ASSRs were calculated. The test time required for the responses to reach significance at 1%, 2%, and 5% F ratios was analyzed. The percentage false response detection rate was calculated to determine the suitability of current ASSR threshold estimation protocols for use in audiology clinics.
The repeatability coefficients for the amplitude of ASSRs were 29 nV for the normal-hearing subjects and 57 nV for the hearing-impaired subjects. The repeatability coefficients for the latency of ASSR were 1.10 msec for the normal-hearing subjects and 1.19 msec for the hearing-impaired subjects. High false-positive detection rates were found for detection procedures that used variable test time ("stop when significance reached" methods).
The results of this study showed that ASSR amplitudes are highly variable between test sessions with an average estimated variability in response amplitude of ± 40% for normal-hearing participants and ± 97% for hearing-impaired participants. This could be a possible cause of test-retest differences in ASSR threshold measurements, as it could potentially lead to thresholds that were above the EEG noise level and significant in one test session subsequently falling below the EEG noise level in the repeat test session leading to insignificant response and thus poorer ASSR threshold.
本研究旨在评估听觉稳态反应（ASSR）振幅的会话间可重复性，并检查 F 比响应检测参数。
从 20 名正常听力和 10 名听力受损受试者中记录阈上 ASSR。在两天的不同时间进行两次测试，记录振幅和潜伏期。
计算 ASSR 振幅和潜伏期的重复性系数（重复测量预期变化的限值）。分析达到 1%、2%和 5%F 比的响应所需的测试时间。计算错误响应检测率的百分比，以确定当前 ASSR 阈值估计协议在听力诊所中的适用性。
正常听力受试者 ASSR 振幅的重复性系数为 29nV，听力受损受试者为 57nV。正常听力受试者 ASSR 潜伏期的重复性系数为 1.10msec，听力受损受试者为 1.19msec。对于使用可变测试时间的检测程序（“达到显著性时停止”方法），发现高假阳性检测率。
本研究结果表明，ASSR 振幅在测试会话之间高度可变，正常听力参与者的平均响应幅度估计变异性为±40%，听力受损参与者的平均响应幅度估计变异性为±97%。这可能是 ASSR 阈值测量中测试-再测试差异的一个可能原因，因为它可能导致阈值高于 EEG 噪声水平，在一次测试会话中显著，而在重复测试会话中随后低于 EEG 噪声水平，导致响应不显著，从而导致 ASSR 阈值较差。
